Document Detail


Increased platelet activation in renal transplant patients.
MedLine Citation:
PMID:  16801096     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with functioning renal transplants are at risk of graft thrombosis in the postoperative period, and of fistula thrombosis and other thrombotic events thereafter. Investigation and therapeutic manipulation of haemostasis in these patients offers a means to counter this thrombotic tendency. METHODS: Platelet aggregation in whole blood, plasma von Willebrand factor and plasma fibrinogen levels were measured in 32 stable renal transplant patients (creatinine <200 micromol/litre, age of graft >4 months) and in 32 age, sex and smoking-habit matched normal controls. RESULTS: In both patient and control groups, seven patients were smokers and the remaining 25 were non-smokers. There was no significant difference in age between patients and controls [patients, median: 39 (20-64) years; controls: 38 (24-60) years]. Spontaneous platelet aggregation was significantly higher in the patients at all time points studied [30s-6 min; at 4 min: patients median (interquartile range) 19.4 (11.3-27.3)%; controls, 8.0 (5.1-15.0)%, P < 0.0005]. ADP-induced aggregation was also increased at a concentration range of 0.1-3 microM (at 1 microM, 1 min, patients median (interquartile range) was 52.4 (30.5-70.0)%; controls was 16.5 (1.4-31.4)%, P < 0.0001). Transplant patients had significantly higher von Willebrand factor and fibrinogen levels compared with the controls (von Willebrand factor, patients median (range): 158 (13-269)%; controls: 85 (43-223)%, P < 0.00001; fibrinogen, patients: 3.29 (2.12-7.39) g/litre; controls: 2.81 (1.84-4.65) g/litre, P < 0.0002). CONCLUSION: Patients with stable renal transplants have in vitro evidence of enhanced platelet activation, and increased plasma von Willebrand factor and fibrinogen levels.
Authors:
J E Taylor; C Porter; S Heptinstall; M McLaren; J J Belch
Related Documents :
21459556 - Temporomandibular joint involvement in rheumatoid arthritis, systemic lupus erythematos...
12614366 - In vivo recovery and safety of human factor viii product aafact in patients with haemop...
22331436 - Supratarsal injection of triamcinolone acetonide and childhood allergic keratoconjuncti...
22819246 - Bronchial hyperresponsiveness in seasonal allergic rhinitis patients is associated with...
2224406 - Does primary fibromyalgia exist?
22864876 - Phase i study of the aurora b kinase inhibitor barasertib (azd1152) to assess the pharm...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Platelets     Volume:  10     ISSN:  0953-7104     ISO Abbreviation:  Platelets     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2006-06-27     Completed Date:  2007-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208117     Medline TA:  Platelets     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  -    
Affiliation:
Renal Unit and Department of Medicine, Nottingham University Teaching Hospitals, Nottingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence of anti-beta(2) glycoprotein-I antibody in patients with primary or secondary immune thro...
Next Document:  Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelet...