Document Detail

Increased plasma nitric oxide level associated with suicide attempt in depressive patients.
MedLine Citation:
PMID:  16725247     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nitric oxide (NO) is known to influence cerebral monoaminergic activity, including the activity of serotonin. We evaluated plasma NO metabolite (NO(x)) levels in depressive patients with and without a recent history of suicide attempt. METHOD: Plasma NO(x) levels were measured in 39 depressive patients who had recently attempted suicide, 44 non-suicidal depressed patients, and 70 normal controls. The severity of depression was measured with the Hamilton's Depression Rating Scale. The lethality of the suicide attempt was scored using Weisman and Worden's risk-rescue rating scale and Lethality Suicide Attempt Rating Scale. RESULTS: Plasma NO(x) levels were significantly higher in suicidal depressive patients than non-suicidal depressive patients or normal control subjects (Z=-2.472, p=0.013). However, higher plasma NO(x) levels in suicidal depressive patients were significantly related to a lower lethality of suicide attempts and lower severity of depression. CONCLUSIONS: Our study suggests that increased plasma NO(x) level is associated with suicide attempts in depressive patients. Moreover, higher plasma NO(x) level is related with suicide attempts in mild depressed patients. However, further studies are required to understand the role of NO system in depression and suicidal behavior.
Yong-Ku Kim; Jong-Woo Paik; Sung-Woo Lee; Dokyung Yoon; Changsu Han; Bun-Hee Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-24
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  30     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1091-6     Citation Subset:  IM    
Department of Psychiatry, Korea University Ansan Hospital, Ansan City, Gojan Dong, 516, Kyunggi Province, 425-020, Korea.
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MeSH Terms
Depressive Disorder / blood*,  psychology*
Middle Aged
Nitric Oxide / blood*
Psychiatric Status Rating Scales
Psychological Tests
Suicide, Attempted / psychology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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