| Increased plasma nitrate levels in patients with crush syndrome in the Marmara earthquake. | |
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MedLine Citation:
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PMID: 12104087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Crush syndrome has been described as extensive muscle damage, leading to acute renal failure. The aim of this study was to evaluate the possible role of nitric oxide, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in crush syndrome. PATIENTS AND METHODS: A total of 17 patients suffering from crush syndrome, 7 patients without crush syndrome and 10 healthy controls were enrolled in the study. Plasma nitrate, TNF-alpha, IL-1 beta levels and biochemical parameters were measured. RESULTS: All patients with crush syndrome demonstrated acute renal failure. Plasma nitrate levels were elevated significantly in the crush syndrome patients compared with patients without crush syndrome (33.5 +/- 20.1 vs. 15.3 +/- 5 micromol/l, p=0.014). There was no significant difference in TNF-alpha and IL-1 beta levels between control and patient groups. CONCLUSION: Increased plasma nitrate levels in the crush syndrome may be related either to the elevated production of NO or the diminished excretion of nitrate or both. |
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Authors:
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Ulver Derici; Ozan Ozkaya; Turgay Arinsoy; Deniz Erbas; Sukru Sindel; Musa Bali; Necla Buyan; Enver Hasanoglu; Oguz Soylemezoglu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 322 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-09 Completed Date: 2002-10-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 99-103 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science B.V. |
Affiliation:
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Department of Nephrology, Gazi University Hospital, 06510 Besevler, Ankara, Turkey. derici@med.gazi.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Crush Syndrome / blood*, complications, metabolism Disasters* Female Humans Interleukin-1 / blood Kidney Failure / blood, complications, metabolism Male Middle Aged Nitrates / blood* Nitric Oxide / metabolism Time Factors Tumor Necrosis Factor-alpha / analysis Turkey |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Nitrates; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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