Document Detail

Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in Type 1 diabetic patients without clinically manifest macroangiopathy.
MedLine Citation:
PMID:  16026364     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate whether plasma biomarkers of inflammation and endothelial dysfunction differed in Type 1 diabetic patients as compared with those in non-diabetic subjects, and to examine the association of these biomarkers with early stages of microvascular complications. METHODS: Plasma biomarkers of inflammation [fibrinogen, hs-C-reactive protein (hs-CRP)] and endothelial dysfunction [von Willebrand factor (v-WF), intercellular adhesion molecule-1, plasminogen activator inhibitor-1 (PAI-1) activity] were measured in 88 non-smoking young patients with Type 1 diabetes without clinical macrovascular disease and in 40 healthy controls. RESULTS: Plasma levels of hs-CRP, fibrinogen, v-WF, soluble intracellular adhesion molecule-1 (sICAM-1) and PAI-1 activity were markedly higher (P < 0.01 or less) in Type 1 diabetic patients than in healthy controls; these results were essentially unchanged when healthy controls were compared with patients without complications. After stratification by microvascular complication status, plasma biomarkers of inflammation and endothelial dysfunction were significantly increased in those with more advanced disease compared with those with early complications or without complications, respectively. However, while the significant differences in these biomarkers were little affected by adjustment for sex, age, BMI and blood pressure values, they were totally abolished after additional adjustment for diabetes duration and glycaemic control. CONCLUSIONS: These results indicate that in Type 1 diabetes there is a subclinical, chronic inflammation which is, at least partly, independent of clinically manifest macro- and microvascular complications, smoking or other traditional cardiovascular risk factors; this subclinical inflammation is closely correlated to the magnitude and duration of hyperglycaemia.
G Targher; L Bertolini; G Zoppini; L Zenari; G Falezza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  22     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  999-1004     Citation Subset:  IM    
Department of Internal Medicine, Sacro Cuore Hospital, Negrar, Italy.
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MeSH Terms
Biological Markers / analysis,  metabolism*
C-Reactive Protein / analysis,  metabolism
Diabetes Complications
Diabetes Mellitus, Type 1 / blood*,  physiopathology
Diabetic Angiopathies / blood,  physiopathology
Endothelium, Vascular / physiopathology*
Fibrinogen / analysis,  metabolism*
Intercellular Adhesion Molecule-1 / analysis,  metabolism*
Receptors, Tumor Necrosis Factor, Type I / analysis,  metabolism*
Receptors, Tumor Necrosis Factor, Type II / analysis,  metabolism*
von Willebrand Factor / analysis,  metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 0/von Willebrand Factor; 126547-89-5/Intercellular Adhesion Molecule-1; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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