Document Detail

Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection.
MedLine Citation:
PMID:  17558349     Owner:  NLM     Status:  MEDLINE    
Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and procalcitonin (PCT) are often considered to be specific markers for infection. We evaluated plasma levels of sTREM-1 and PCT in patients with systemic inflammatory response syndrome but no sepsis. Noninfected patients undergoing elective heart surgery with cardiopulmonary bypass (n = 76) and patients admitted after out-of-hospital cardiac arrest (n = 54) were followed up for 3 days. Patients with severe sepsis (n = 55) and healthy volunteers (n = 31) were included as positive and negative controls, respectively. Plasma levels of PCT were higher in sepsis patients than in patients who survived after cardiac arrest or after heart surgery. In contrast, peak plasma levels of sTREM-1 in heart surgery and in cardiac arrest patients overlapped with those measured in patients with sepsis. Both sTREM-1 and PCT were significantly higher in cardiac arrest patients who died of refractory shock than in those who died of neurological failure or survived without major neurological damage. In the cardiac arrest patients with refractory shock, sTREM-1 and PCT levels were similar to those in the patients with severe sepsis. In conclusion, sTREM-1 and PCT are not specific for infection and can increase markedly in acute inflammation without infection.
Minou Adib-Conquy; Mehran Monchi; Cyril Goulenok; Ivan Laurent; Marie Thuong; Jean-Marc Cavaillon; Christophe Adrie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  28     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-12     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-10     Citation Subset:  IM    
Cytokines & Inflammation Unit, Institute Pasteur, Paris, France.
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MeSH Terms
C-Reactive Protein / metabolism
Calcitonin / blood*
Case-Control Studies
Heart Arrest / blood*
Membrane Glycoproteins / blood*
Middle Aged
Protein Precursors / blood*
Receptors, Immunologic / blood*
Sepsis / blood
Thoracic Surgery
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Protein Precursors; 0/Receptors, Immunologic; 0/TREM1 protein, human; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

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