| Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 8393399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied atrial natriuretic factor (ANF), plasma renin activity (PRA), and plasma levels of leukotrienes (LTs) B4 and C4 in 23 patients with COPD undergoing right cardiac catheterization for suspected pulmonary hypertension. Hemodynamic measurements together with concomitant ANF levels (both in venous and pulmonary artery blood and right atrial and pulmonary artery plasma levels of LTC4 and LTB4, were determined at rest (T0), after 30 min of breathing oxygen (3 L/min) (T1), and after 30 min recovering and breathing air (T2). Patients with effective exacerbation or definitive evidence of left ventricular disease, hypertension, arrhythmias, or vasodilator or diuretic therapy were excluded. Increased levels of ANF, both in peripheral venous blood (117 +/- 65 pg/ml) and the pulmonary artery (153 +/- 75 pg/ml), were found in patients with COPD, with or without pulmonary hypertension. Levels of LTC4 were also significantly increased (366 +/- 406 pg/ml) when compared with our control values. No correlations among ANF, LTC4 values, functional tests, and hemodynamic measurements were found. Brief increased levels of oxygen did not modify ANF or LTC4 plasma levels, either in patients with or without pulmonary hypertension. |
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Authors:
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D Piperno; Y Pacheco; R Hosni; P Moliere; C Gharib; M Lagarde; M Perrin-Fayolle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 104 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-09-02 Completed Date: 1993-09-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: AIM; IM; S |
Affiliation:
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Department of Lung Medicine, Centre Hospitalo Universitaire, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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blood* Hemodynamics Humans Hypertension, Pulmonary / etiology Leukotriene B4 / blood Lung Diseases, Obstructive / blood*, complications, physiopathology, therapy Middle Aged Oxygen Inhalation Therapy Renin / blood* Respiratory Mechanics SRS-A / blood* |
| Chemical | |
Reg. No./Substance:
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0/SRS-A; 71160-24-2/Leukotriene B4; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
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