Document Detail

Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  8393399     Owner:  NLM     Status:  MEDLINE    
We studied atrial natriuretic factor (ANF), plasma renin activity (PRA), and plasma levels of leukotrienes (LTs) B4 and C4 in 23 patients with COPD undergoing right cardiac catheterization for suspected pulmonary hypertension. Hemodynamic measurements together with concomitant ANF levels (both in venous and pulmonary artery blood and right atrial and pulmonary artery plasma levels of LTC4 and LTB4, were determined at rest (T0), after 30 min of breathing oxygen (3 L/min) (T1), and after 30 min recovering and breathing air (T2). Patients with effective exacerbation or definitive evidence of left ventricular disease, hypertension, arrhythmias, or vasodilator or diuretic therapy were excluded. Increased levels of ANF, both in peripheral venous blood (117 +/- 65 pg/ml) and the pulmonary artery (153 +/- 75 pg/ml), were found in patients with COPD, with or without pulmonary hypertension. Levels of LTC4 were also significantly increased (366 +/- 406 pg/ml) when compared with our control values. No correlations among ANF, LTC4 values, functional tests, and hemodynamic measurements were found. Brief increased levels of oxygen did not modify ANF or LTC4 plasma levels, either in patients with or without pulmonary hypertension.
D Piperno; Y Pacheco; R Hosni; P Moliere; C Gharib; M Lagarde; M Perrin-Fayolle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  104     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  454-9     Citation Subset:  AIM; IM; S    
Department of Lung Medicine, Centre Hospitalo Universitaire, Lyon, France.
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MeSH Terms
Atrial Natriuretic Factor / blood*
Hypertension, Pulmonary / etiology
Leukotriene B4 / blood
Lung Diseases, Obstructive / blood*,  complications,  physiopathology,  therapy
Middle Aged
Oxygen Inhalation Therapy
Renin / blood*
Respiratory Mechanics
SRS-A / blood*
Reg. No./Substance:
0/SRS-A; 71160-24-2/Leukotriene B4; 85637-73-6/Atrial Natriuretic Factor; EC

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