Document Detail


Increased plasma concentrations of antiprothrombin antibodies in women with recurrent spontaneous abortions.
MedLine Citation:
PMID:  17158197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antiphospholipid antibodies are associated with recurrent fetal loss, but the clinical relevance of antiprothrombin (aPT) antibodies remains controversial. This study was designed to evaluate the relationship of plasma concentrations of aPT antibodies (IgG, IgM, and IgA isotypes) and recurrent spontaneous abortion (RSA) not associated with antiphospholipid-antibody syndrome. METHODS: In this retrospective case-control study, we measured plasma aPT antibodies in 100 pregnant women at 8-12 weeks of gestation who had histories of recurrent abortion not associated with antiphospholipid-antibody syndrome. The controls were 200 healthy gestational-age-matched women with uncomplicated gestations. RESULTS: The mean (SD) plasma aPT concentrations were significantly (P <0.001) higher in women with histories of recurrent abortion than in healthy controls [7.97 (0.79) and 2.08 (0.07) kU/L]. Similarly, the concentrations of IgM aPT were significantly (P <0.001) higher in patients than in controls [5.73 (0.85) and 1.83 (0.05) kU/L]. No differences were found for IgA aPT (P = 0.358). CONCLUSIONS: High concentrations of aPT antibodies (IgG and IgM isotypes) are associated with pregnancy loss in women with RSA. We suggest that the antibodies may have a relevant role in the etiology and pathogenesis of the condition.
Authors:
Laura Sabatini; Michela Torricelli; Valentina Scaccia; Daniela Fineschi; Monica Pescaglini; Laura Gasparri; Pasquale Florio; Felice Petraglia
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Publication Detail:
Type:  Journal Article     Date:  2006-12-07
Journal Detail:
Title:  Clinical chemistry     Volume:  53     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-32     Citation Subset:  IM    
Affiliation:
L'Unità Operativa Laboratorio di Ematologia e Coagulazione, Azienda Ospedaliera Senese, Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / immunology*
Adult
Antibodies, Antiphospholipid / blood
Autoantibodies / blood*
Female
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Middle Aged
Pregnancy
Recurrence
Retrospective Studies
Thrombin / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; EC 3.4.21.5/Thrombin

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