Document Detail

Increased plasma adrenomedullin in women with recurrent pregnancy loss.
MedLine Citation:
PMID:  12907107     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate vascular changes and uterine perfusion in women with recurrent pregnancy loss. METHODS: We measured plasma levels of adrenomedullin of 100 pregnant women in the midluteal phase of a nonpregnant cycle (control group: n = 62; recurrent pregnancy loss group: n = 38). We measured the pulsatility index (PI) in the uterine arteries by transvaginal pulsed Doppler ultrasonography at the same time. RESULTS: The plasma level of adrenomedullin in women with recurrent pregnancy loss (5.6 +/- 1.9, mean +/- standard deviation) was significantly higher (P >.001) than that in control women (3.6 +/- 1.7). Uterine arterial PI of women with recurrent pregnancy loss (2.70 +/- 0.47) was significantly higher (P >.001) than that in control women (2.09 +/- 0.39). Plasma level of adrenomedullin had a significant positive correlation with uterine arterial PI both in the control group (r =.58, P <.001) and in the recurrent pregnancy loss group (r =.78, P <.001). Both plasma adrenomedullin concentration (7.2 +/- 2.3) and uterine arterial PI (3.06 +/- 0.36) were significantly high in women with antiphospholipid antibodies. CONCLUSION: Plasma adrenomedullin may serve as a useful biochemical marker for recurrent pregnancy loss caused by impaired uterine perfusion.
Mikiya Nakatsuka; Toshihiro Habara; Soichi Noguchi; Hideki Konishi; Takafumi Kudo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  102     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-08-29     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan.
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MeSH Terms
Abortion, Habitual / blood*,  physiopathology
Antibodies, Antiphospholipid / analysis
Endometrium / pathology
Luteal Phase / physiology
Peptides / blood*
Prospective Studies
Ultrasonography, Doppler, Pulsed
Uterus / blood supply
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Peptides; 148498-78-6/Adrenomedullin

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