| Increased plasma adrenomedullin in women with recurrent pregnancy loss. | |
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MedLine Citation:
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PMID: 12907107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate vascular changes and uterine perfusion in women with recurrent pregnancy loss. METHODS: We measured plasma levels of adrenomedullin of 100 pregnant women in the midluteal phase of a nonpregnant cycle (control group: n = 62; recurrent pregnancy loss group: n = 38). We measured the pulsatility index (PI) in the uterine arteries by transvaginal pulsed Doppler ultrasonography at the same time. RESULTS: The plasma level of adrenomedullin in women with recurrent pregnancy loss (5.6 +/- 1.9, mean +/- standard deviation) was significantly higher (P >.001) than that in control women (3.6 +/- 1.7). Uterine arterial PI of women with recurrent pregnancy loss (2.70 +/- 0.47) was significantly higher (P >.001) than that in control women (2.09 +/- 0.39). Plasma level of adrenomedullin had a significant positive correlation with uterine arterial PI both in the control group (r =.58, P <.001) and in the recurrent pregnancy loss group (r =.78, P <.001). Both plasma adrenomedullin concentration (7.2 +/- 2.3) and uterine arterial PI (3.06 +/- 0.36) were significantly high in women with antiphospholipid antibodies. CONCLUSION: Plasma adrenomedullin may serve as a useful biochemical marker for recurrent pregnancy loss caused by impaired uterine perfusion. |
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Authors:
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Mikiya Nakatsuka; Toshihiro Habara; Soichi Noguchi; Hideki Konishi; Takafumi Kudo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 102 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-08 Completed Date: 2003-08-29 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan. mikiya@cc.okayama-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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blood*,
physiopathology Adrenomedullin Adult Antibodies, Antiphospholipid / analysis Endometrium / pathology Female Humans Luteal Phase / physiology Peptides / blood* Prospective Studies Ultrasonography, Doppler, Pulsed Uterus / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid; 0/Peptides; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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