Document Detail

Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow.
MedLine Citation:
PMID:  17706955     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Slow coronary filling of epicardial coronary arteries in the absence of stenosis is not infrequently detected finding during routine coronary angiography. There is mounting evidence suggested that an inflammatory process play an important role in atherosclerotic pathogenesis appeared in different clinical settings. However, the possible association between inflammation and slow coronary flow (SCF) has not been investigated. We examined whether the increased inflammatory markers are present in patients with SCF. METHODS: Forty-two patients with SCF detected by coronary angiography via the Thrombosis In Myocardial Infarction (TIMI) frame count method were enrolled in this study. The plasma concentration of high-sensitivity C-reactive protein (CRP) and interleukin-6 (IL-6) were evaluated using commercial available kits. Data were compared with 30 control subjects with angiographically normal coronary flow. RESULTS: There are no differences regarding clinical characteristics between the 2 groups. The data showed, however, that plasma CRP and IL-6 concentrations were higher in patients with SCF compared with normal control subject (CRP: 0.27 +/- 0.16 vs. 0.22 +/- 0.11mg/l; and IL-6: 8.7 +/- 0.8 vs. 5.4 +/- 0.4pg/ml, p < 0.01 respectively). In addition, mean TIMI frame count was positively correlated with plasma CRP and IL-6 concentrations (CRP: gamma = 0.551; IL-6: gamma = 0.573, p < 0.01 respectively). CONCLUSIONS: Plasma concentration of CRP and IL-6 concentrations increased, and was positive correlated with TIMI frame count in patients with SCF compared with normal coronary flow subject. Therefore, whether the increased inflammatory markers are related to the pathogenesis of SCF in these patients deserved further investigation.
Jian-Jun Li; Xue-Wen Qin; Zi-Cheng Li; He-Song Zeng; Zhan Gao; Bo Xu; Chao-Yang Zhang; Jie Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-15
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  385     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, People's Republic of China.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism*
Coronary Circulation*
Coronary Disease / blood*,  pathology
Inflammation / blood,  pathology
Interleukin-6 / blood*
Middle Aged
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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