Document Detail

Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency.
MedLine Citation:
PMID:  9950149     Owner:  NLM     Status:  MEDLINE    
Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status. In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs. Concentrations of IRP-1, IRP-2 and TfR mRNA were measured in 10 placentae obtained from diabetic and non-diabetic human pregnancies with a wide range of fetoplacental iron status. IRP-1 activity was present in human placenta and correlated closely with TfR mRNA concentration (r=0.82; P=0.007). IRP-2 activity and protein were not detected. In a second experiment, placentae were collected from 12 diabetic pregnancies, six with low fetal cord serum ferritin and placental non-heme iron concentrations, and six with normal iron status. IRP-1 activity and TfR Bmax for diferric transferrin were greater in the iron-deficient group (P<0.05). IRP-1 activity correlated inversely with cord serum ferritin (r=0.75; P<0.01) and placental non-heme iron (r=0.61; P=0.05) concentration. Placental IRP-1 activity is directly related to TfR mRNA concentration and is more highly expressed in iron-deficient placentae. The study provides direct in vivo evidence for IRP regulation of TfR expression in the human placenta.
M K Georgieff; S A Berry; J D Wobken; E A Leibold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  20     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-29     Completed Date:  1999-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, USA.
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MeSH Terms
Blotting, Northern
Ferritins / blood
Fetal Blood / metabolism
Fetal Diseases / etiology*
Gene Expression*
Guinea Pigs
Iron / deficiency*
Iron Regulatory Protein 1
Iron Regulatory Protein 2
Iron-Regulatory Proteins
Iron-Sulfur Proteins / genetics*
Placenta / chemistry,  metabolism*
Pregnancy in Diabetics / complications,  metabolism*
RNA, Messenger / analysis,  metabolism
RNA-Binding Proteins / genetics*
Receptors, Transferrin / genetics
Reg. No./Substance:
0/Iron-Regulatory Proteins; 0/Iron-Sulfur Proteins; 0/RNA, Messenger; 0/RNA-Binding Proteins; 0/Receptors, Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins; EC Regulatory Protein 1; EC Regulatory Protein 2

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