Document Detail


Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins.
MedLine Citation:
PMID:  17053033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise is considered to be beneficial for free fatty acid (FFA) metabolism, although reports of the effects of increased physical activity on FFA uptake and oxidation in different tissues in vivo in humans have been inconsistent. To investigate the heredity-independent effects of physical activity and fitness on FFA uptake in skeletal muscle, the myocardium, and liver we used positron emission tomography (PET) in nine healthy young male monozygotic twin pairs discordant for physical activity and fitness. The cotwins with higher physical activity constituting the more active group had a similar body mass index but less body fat and 18 +/- 10% higher (P < 0.001) compared to the less active brothers with lower physical activity. Low-intensity knee-extension exercise increased skeletal muscle FFA and oxygen uptake six to 10 times compared to resting values but no differences were observed between the groups at rest or during exercise. At rest the more active group had lower hepatic FFA uptake compared to the less active group (5.5 +/- 4.3 versus 9.0 +/- 6.1 micromol (100 ml)(-1) min(-1), P = 0.04). Hepatic FFA uptake associated significantly with body fat percentage (P = 0.05). Myocardial FFA uptake was similar between the groups. In conclusion, in the absence of the confounding effects of genetic factors, moderately increased physical activity and aerobic fitness decrease body adiposity even in normal-weighted healthy young adult men. Further, increased physical activity together with decreased intra-abdominal adiposity seems to decrease hepatic FFA uptake but has no effects on skeletal muscle or myocardial FFA uptake.
Authors:
Jarna C Hannukainen; Pirjo Nuutila; Ronald Borra; Borra Ronald; Jaakko Kaprio; Urho M Kujala; Tuula Janatuinen; Olli J Heinonen; Jukka Kapanen; Tapio Viljanen; Merja Haaparanta; Tapani Rönnemaa; Riitta Parkkola; Juhani Knuuti; Kari K Kalliokoski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-10-19
Journal Detail:
Title:  The Journal of physiology     Volume:  578     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-02-26     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-58     Citation Subset:  IM    
Affiliation:
Turku PET Centre, University of Turku, Turku, Finland. jarna.hannukainen@tyks.fi
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Anaerobic Threshold / physiology
Anthropometry
Body Composition / physiology
Cohort Studies
Fatty Acids, Nonesterified / metabolism*
Humans
Image Interpretation, Computer-Assisted
Liver / metabolism*,  physiology*,  radionuclide imaging
Motor Activity / physiology*
Muscle, Skeletal / metabolism
Myocardium / metabolism
Oxygen Consumption / physiology
Physical Fitness / physiology
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use
Twins, Monozygotic
Grant Support
ID/Acronym/Agency:
AA08315/AA/NIAAA NIH HHS; AA12502/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Radiopharmaceuticals
Comments/Corrections
Erratum In:
J Physiol. 2008 Jan;586(1):311
Note: Ronald, Borra [corrected to Borra, Ronald]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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