| Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins. | |
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MedLine Citation:
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PMID: 17053033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise is considered to be beneficial for free fatty acid (FFA) metabolism, although reports of the effects of increased physical activity on FFA uptake and oxidation in different tissues in vivo in humans have been inconsistent. To investigate the heredity-independent effects of physical activity and fitness on FFA uptake in skeletal muscle, the myocardium, and liver we used positron emission tomography (PET) in nine healthy young male monozygotic twin pairs discordant for physical activity and fitness. The cotwins with higher physical activity constituting the more active group had a similar body mass index but less body fat and 18 +/- 10% higher (P < 0.001) compared to the less active brothers with lower physical activity. Low-intensity knee-extension exercise increased skeletal muscle FFA and oxygen uptake six to 10 times compared to resting values but no differences were observed between the groups at rest or during exercise. At rest the more active group had lower hepatic FFA uptake compared to the less active group (5.5 +/- 4.3 versus 9.0 +/- 6.1 micromol (100 ml)(-1) min(-1), P = 0.04). Hepatic FFA uptake associated significantly with body fat percentage (P = 0.05). Myocardial FFA uptake was similar between the groups. In conclusion, in the absence of the confounding effects of genetic factors, moderately increased physical activity and aerobic fitness decrease body adiposity even in normal-weighted healthy young adult men. Further, increased physical activity together with decreased intra-abdominal adiposity seems to decrease hepatic FFA uptake but has no effects on skeletal muscle or myocardial FFA uptake. |
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Authors:
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Jarna C Hannukainen; Pirjo Nuutila; Ronald Borra; Borra Ronald; Jaakko Kaprio; Urho M Kujala; Tuula Janatuinen; Olli J Heinonen; Jukka Kapanen; Tapio Viljanen; Merja Haaparanta; Tapani Rönnemaa; Riitta Parkkola; Juhani Knuuti; Kari K Kalliokoski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-10-19 |
Journal Detail:
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Title: The Journal of physiology Volume: 578 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-01 Completed Date: 2007-02-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 347-58 Citation Subset: IM |
Affiliation:
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Turku PET Centre, University of Turku, Turku, Finland. jarna.hannukainen@tyks.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Anaerobic Threshold / physiology Anthropometry Body Composition / physiology Cohort Studies Fatty Acids, Nonesterified / metabolism* Humans Image Interpretation, Computer-Assisted Liver / metabolism*, physiology*, radionuclide imaging Motor Activity / physiology* Muscle, Skeletal / metabolism Myocardium / metabolism Oxygen Consumption / physiology Physical Fitness / physiology Positron-Emission Tomography Radiopharmaceuticals / diagnostic use Twins, Monozygotic |
| Grant Support | |
ID/Acronym/Agency:
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AA08315/AA/NIAAA NIH HHS; AA12502/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Radiopharmaceuticals |
| Comments/Corrections | |
Erratum In:
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J Physiol. 2008 Jan;586(1):311 Note: Ronald, Borra [corrected to Borra, Ronald] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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