Document Detail

Increased peripheral release of noradrenaline and uptake of adrenaline in essential hypertension?
MedLine Citation:
PMID:  7318326     Owner:  NLM     Status:  MEDLINE    
1. Twenty middle-aged men with untreated sustained essential hypertension for more than 5 years and 19 comparable normotensive controls were investigated. Both groups were derived from The Oslo Study, where they had served as control hypertensive and normotensive subjects. 2. Supine venous and arterial plasma catecholamines were increased in the hypertensive subjects compared with the normotensive subjects. The mean arterial--venous difference for adrenaline in the hypertensive (0.45 +/- SE 0.08 nmol/l) was increased compared with the normotensive group (0.27 +/- 0.03 nmol/l, P less than 0.05). Similarly, the venous--arterial difference for noradrenaline was increased in the hypertensive (0.29 +/- 0.13 nmol/l, P less than 0.05) compared with the normotensive group (-0.07 +/- 0.11 nmol/l). 3. The results are consistent with an increased release of adrenaline from the adrenal medulla and noradrenaline from the peripheral vascular beds (forearm) in essential hypertension. The increased arterial--venous difference for adrenaline in the hypertensive group also suggests an increased uptake of adrenaline in the peripheral vascular beds.
S E Kjeldsen; B Flaaten; I Eide; A Helgeland; P Leren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  61 Suppl 7     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215s-217s     Citation Subset:  IM    
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MeSH Terms
Epinephrine / blood*
Femoral Artery
Forearm / blood supply
Hypertension / blood*
Middle Aged
Norepinephrine / blood*
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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