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MedLine Citation:
PMID:  21535126     Owner:  NLM     Status:  Publisher    
Background:  Children with myelomeningocele (MMC) run an increased risk of developing early or precocious puberty (E/PP). Aim:  To identify risk factors for E/PP in boys with MMC. Methods:  Boys born 1970-92, treated for MMC at the University Children's Hospital, Uppsala, were identified. 38 boys were possible to include. Medical records were examined retrospectively. Early puberty was defined as pubertal signs before the age of 10 years and 2 months. Precocious puberty was defined as appearance of these signs before 9 years of age. Increased intracranial pressure perinatally was defined as wide sutures, bulging fontanelles and increased/increasing head circumference at birth and/or during the first week after birth. Early brainstem dysfunction was defined as severe and persistent feeding and respiratory problems before the age of 3 months despite proper control of the hydrocephalus. Results:  Of the 38 boys, 8 (21%) had E/PP, which was strongly associated with increased intracranial pressure perinatally and also with early brainstem dysfunction. Multivariate regression analysis showed early brainstem dysfunction to have the highest explanatory value regarding the occurrence of early puberty. Conclusion:  Increased intracranial pressure perinatally as well as brainstem dysfunction early in life are strong predictors of E/PP in boys with MMC.
Lemm A Proos; Torsten Tuvemo; Gunnnar Ahlsten; Jan Gustafsson; Margareta Dahl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-29
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
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