Document Detail

Increased perinatal intracranial pressure and brainstem dysfunction predict early puberty in boys with myelomeningocele.
MedLine Citation:
PMID:  21535126     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Children with myelomeningocele (MMC) run an increased risk of developing early or precocious puberty (E/PP).
AIM:   To identify risk factors for E/PP in boys with MMC.
METHODS: Boys born between 1970 and 1992, treated for MMC at the University Children's Hospital, Uppsala, were identified. Thirty-eight boys were eligible to be included. Medical records were examined retrospectively. Early puberty was defined as pubertal signs before the age of 10 years and 2 months. Precocious puberty was defined as the appearance of these signs before 9 years of age. Increased intracranial pressure perinatally was defined as wide sutures, bulging fontanelles and increased/increasing head circumference at birth and/or during the first week after birth. Early brainstem dysfunction was defined as severe and persistent feeding and respiratory problems before the age of 3 months despite proper control of the hydrocephalus.
RESULTS: Of the 38 boys, 8 (21%) had E/PP, which was strongly associated with increased intracranial pressure perinatally and also with early brainstem dysfunction. Multivariate regression analysis showed early brainstem dysfunction to have the highest explanatory value regarding the occurrence of early puberty.
CONCLUSION: Increased intracranial pressure perinatally and brainstem dysfunction early in life are strong predictors of E/PP in boys with MMC.
Lemm A Proos; Torsten Tuvemo; Gunnar Ahlsten; Jan Gustafsson; Margareta Dahl
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Publication Detail:
Type:  Journal Article     Date:  2011-05-25
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  100     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-15     Completed Date:  2012-03-29     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1368-72     Citation Subset:  IM    
Copyright Information:
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.
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MeSH Terms
Brain Stem / physiopathology*
Feeding and Eating Disorders of Childhood / etiology
Hydrocephalus / etiology
Infant, Newborn
Intracranial Hypertension / complications*
Meningomyelocele / complications,  physiopathology*
Multivariate Analysis
Puberty, Precocious / epidemiology,  etiology*
Regression Analysis
Respiration Disorders / etiology
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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