Document Detail


Increased pericardial fluid concentrations of the mature form of adrenomedullin in patients with cardiac remodelling.
MedLine Citation:
PMID:  11847163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is evidence that adrenomedullin has autocrine or paracrine activities that oppose cardiac remodelling. However, it remains unclear whether it exerts those local functions in heart failure patients.
OBJECTIVE: To investigate the relation between plasma and pericardial fluid concentrations of adrenomedullin and left ventricular haemodynamic variables.
DESIGN: Samples of plasma and pericardial fluid were obtained from 50 patients undergoing cardiac surgery. They were classified into two groups: group N (n = 27) with a left ventricular end diastolic volume index (LVEDVI) < or = 90 ml/m(2); and group R (n = 23) with LVEDVI > 90 ml/m(2). Plasma and pericardial fluid concentrations of total adrenomedullin (tAM) and mature adrenomedullin (mAM) were measured and related to the preoperative haemodynamic variables.
RESULTS: Pericardial fluid concentrations of mAM were much higher than the plasma concentration in both group N and group R (mean (SEM), 10.6 (1.7) v 3.3 (0.2) fmol/ml, p = 0.0001; and 21.2 (2.8) v 3.9 (0.3) fmol/ml, p < 0.0001, respectively). The ratio mAM/tAM in pericardial fluid was significantly higher than in plasma (0.56 (0.02) v 0.28 (0.02), p < 0.0001). Pericardial fluid concentrations of mAM, but not plasma concentrations, were significantly correlated with LVEDVI, left ventricular end systolic volume index, left ventricular ejection fraction, and left ventricular mass index (r = 0.60, 0.63, -0.54, and 0.47, respectively).
CONCLUSIONS: Raised pericardial fluid concentrations of mAM may reflect the actions of adrenomedullin as a local mediator against cardiac remodelling in patients with left ventricular dysfunction.
Authors:
K Tambara; M Fujita; N Nagaya; S Miyamoto; A Iwakura; K Doi; G Sakaguchi; K Nishimura; K Kangawa; M Komeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  87     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-02-26     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Aged
Aged, 80 and over
Aorta, Thoracic
Aortic Diseases / metabolism,  surgery
Biological Markers / analysis
Body Fluids / chemistry
Female
Heart Diseases / metabolism,  surgery
Humans
Male
Middle Aged
Peptides / metabolism*
Pericardium / chemistry*
Ventricular Dysfunction, Left / metabolism,  surgery
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptides; 148498-78-6/Adrenomedullin
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