| Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era. | |
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MedLine Citation:
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PMID: 20178139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of these, serotypes 15A (11%), 23A (8%), 35B (8%), and 6C (5%) were most common (cumulatively 32% of penicillin-nonsusceptible isolates). Each except 6C represented a single serotype and clonal complex combination that predated the introduction of PCV7. We evaluated the genetic characteristics and nonsusceptibility to penicillin of non- PCV7 serotypes, and we found increased proportions of specific penicillin-nonsusceptible clones in serotypes 15A, 23A, 35B, and 6C, which potentially indicates a basic change of population structure within these individual serotypes. |
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Authors:
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Robert E Gertz; Zhongya Li; Fabiana C Pimenta; Delois Jackson; Billie A Juni; Ruth Lynfield; James H Jorgensen; Maria da Gloria Carvalho; Bernard W Beall; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 201 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 770-5 Citation Subset: AIM; IM |
Affiliation:
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Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Bacterial Typing Techniques Child Child, Preschool Cluster Analysis DNA Fingerprinting Female Genotype Humans Infant Infant, Newborn Male Penicillin Resistance* Penicillins / pharmacology* Pneumococcal Infections / microbiology* Pneumococcal Vaccines / immunology* Prevalence Sequence Analysis, DNA Serotyping Streptococcus pneumoniae / classification*, drug effects*, isolation & purification United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Penicillins; 0/Pneumococcal Vaccines; 0/heptavalent pneumococcal conjugate vaccine |
| Investigator | |
Investigator/Affiliation:
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Gretchen Rothrock / ; Pam Daily / ; Susan Brooks / ; Joelle Nadle / ; Mirasol Apostol / ; Susan Petit / ; M Zachariah Fraser / ; Nancy Barrett / ; Paul Malpiedi / ; Wendy Baughman / ; Kathryn E Arnold / ; Kim D Holmes / ; Elisabeth A Vaeth / ; Catherine Lexau / ; Lindsey Lesher / ; Lori Triden / ; Bridget Anderson / ; Shelley Zansky / ; Glenda Smith / ; Christine Long / ; Mark Schmidt / ; Karen Stefonek / ; Brenda Barnes / ; Terry McMinn / ; Chris Van Beneden / ; Tami H Skoff / ; Carolyn Wright / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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