Document Detail


Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.
MedLine Citation:
PMID:  11797831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.
Authors:
P J O'Connor; F MacNaught; W H Butler; D P Cooper; G P Margison; A C Povey
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  20     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-18     Completed Date:  2002-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Affiliation:
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Diet
Drug Interactions
Insecticides / administration & dosage,  adverse effects*
Ivermectin / administration & dosage,  adverse effects*
Male
Methylnitronitrosoguanidine / adverse effects*
Mutagens / adverse effects*
Precancerous Conditions / chemically induced*,  veterinary
Rats
Rats, Wistar
Severity of Illness Index
Stomach Neoplasms / chemically induced*,  pathology,  veterinary
Chemical
Reg. No./Substance:
0/Insecticides; 0/Mutagens; 70-25-7/Methylnitronitrosoguanidine; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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