Document Detail

Increased oxygen pulse after lung volume reduction surgery is associated with reduced dynamic hyperinflation.
MedLine Citation:
PMID:  22267766     Owner:  NLM     Status:  MEDLINE    
Stroke volume augmentation during exercise is limited in chronic obstructive pulmonary disease patients because of decreased preload from dynamic hyperinflation (DH). We hypothesised that oxygen pulse and pulse pressure (PP) improve following lung volume reduction surgery (LVRS), and the magnitude of improvement correlates with reduction in DH. We compared 16 emphysema patients undergoing LVRS with six emphysema patients not undergoing LVRS. Oxygen pulse and PP were calculated from maximal cardiopulmonary exercise tests at baseline and 6 months. End-expiratory lung volume (EELV)/total lung capacity (TLC) represented DH. Comparisons were made between baseline and 6 months at metabolic isotimes (per cent maximal carbon dioxide production (V'(CO(2),max))). At baseline, the LVRS group was older with higher forced expiratory volume in 1 s, but had similar hyperinflation to the non-LVRS group. At 6 months, oxygen pulse (50%, 75%, and 100% V'(CO(2),max)) and PP (50% and 75% V'(CO(2),max)) increased in the LVRS, but not in the non-LVRS group. Baseline functional residual capacity/TLC inversely correlated with resting oxygen pulse (r= -0.449, p=0.04). Decreased EELV/TLC correlated with increased oxygen pulse at 75% (r= -0.487, p=0.02) and 100% V'(CO(2),max) (r= -0.548, p=0.008). LVRS led to increased oxygen pulse and PP during exercise at metabolic isotimes 6 months following surgery. Reductions in DH correlated with increases in oxygen pulse during exercise. Reducing lung volume may improve stroke volume response to exercise by decreasing DH.
Matthew R Lammi; David Ciccolella; Nathaniel Marchetti; Malcolm Kohler; Gerard J Criner
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Publication Detail:
Type:  Journal Article     Date:  2012-01-20
Journal Detail:
Title:  The European respiratory journal     Volume:  40     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-03-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  837-43     Citation Subset:  IM    
Section of Pulmonary and Critical Care Medicine, Temple University Hospital, 3401 N. Broad St, 7th floor Parkinson Pavilion, Philadelphia, PA 19140, USA.
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MeSH Terms
Blood Pressure
Breath Tests
Exercise Test
Heart / physiopathology*
Lung / physiopathology*
Middle Aged
Partial Pressure
Pulmonary Disease, Chronic Obstructive / surgery*
Pulmonary Emphysema / physiopathology,  surgery*
Retrospective Studies
Stroke Volume
Total Lung Capacity
Treatment Outcome
Reg. No./Substance:

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