| Increased oxygen pressure to improve the efficiency of membrane oxygenators. | |
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MedLine Citation:
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PMID: 1012109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased O2 pressure was used in a specially constructed oxygenator to test the concept of improved oxygen transfer with hyperbaria. Three membranes were tested: 5-mil Silastic, 1-mil copolymer, and 0.5-mil Teflon. Results are analyzed in terms of pressure, venous saturation, and flow. The 5-mil Silastic proved to be the most reliable and efficient at all levels of saturation and pressure. Oxygen transfers up to 100 cc/m2/min were recorded at lower venous saturations. Normal pCO2 differentials were maintained at atmospheric pressure but decreased as pressure increased. For the Silastic and copolymer membranes, peak efficiency for O2 transfer was at oxygen pressure 3 lb/in2, or 140 mmHg. This usually required a blood pressure of over 300 mmHg using an average blood layer of 0.5 mm. Changes of pressure were more critical than flow, although O2 transfer was found to increase up to flows of 1200 cc/min/m2. Pressure levels of 0-30 lb/in2 were tested. Teflon was most efficient at pressures of 10-15 lb/in2, and did not transfer CO2 in detectable amounts at these pressure levels. Plasma hemoglobin, WBC, and platelets were not seriously altered when studied over 4-hour periods at constant pressures. |
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Authors:
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A A Lefemine; M Lewis; L Bertulli |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Medical instrumentation Volume: 10 ISSN: 0090-6689 ISO Abbreviation: Med Instrum Publication Date: 1976 Nov-Dec |
Date Detail:
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Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361136 Medline TA: Med Instrum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 304-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Dogs Humans Oxygen Oxygenators, Membrane / instrumentation* Permeability Pressure Silicon Time Factors |
| Chemical | |
Reg. No./Substance:
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7440-21-3/Silicon; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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