Document Detail


Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion.
MedLine Citation:
PMID:  9550507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The purpose of our study was to investigate the relationship between misery perfusion (increased oxygen extraction fraction, OEF) and baseline risk factors in patients with carotid occlusion. METHODS: One-hundred seventeen patients with atherosclerotic carotid occlusion were studied prospectively by clinical evaluation, laboratory testing, and positron emission tomography (PET). PET measurements of cerebral blood flow (CBF), cerebral blood volume (CBV), and OEF were made on enrollment in the study. Increased ipsilateral OEF was identified by comparison with 18 normal control subjects. Twenty-five baseline clinical, epidemiological, and arteriographic risk factors were assessed on study entry. Student t tests, chi(2) tests, and Fisher exact tests with Bonferroni correction were used to assess statistical significance (P<.05). RESULTS: Of 117 patients, 44 had increased OEF distal to the occluded carotid and 73 had normal OEFs. Thirty-nine of the 81 patients with prior ipsilateral ischemic symptoms had high OEFs (42%), whereas only 5 of the 31 asymptomatic patients had high OEFs (16%, P<.001). All of the other baseline risk factors were similar between the two groups of patients. CONCLUSIONS: Investigations of the relationship between hemodynamic factors and stroke risk must take into account the lower frequency of hemodynamic abnormalities in asymptomatic patients.
Authors:
C P Derdeyn; K D Yundt; T O Videen; D A Carpenter; R L Grubb; W J Powers
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  29     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-01     Completed Date:  1998-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  754-8     Citation Subset:  IM    
Affiliation:
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. derdeyn@mirlink.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arterial Occlusive Diseases / blood*,  epidemiology
Carotid Arteries / radiography
Carotid Artery Diseases / blood*,  epidemiology
Hemodynamics / physiology*
Homeostasis
Humans
Ischemic Attack, Transient / complications*
Middle Aged
Oxygen / blood*
Oxygen Consumption*
Prospective Studies
Risk Factors
Vasodilation / physiology
Grant Support
ID/Acronym/Agency:
NS28947/NS/NINDS NIH HHS; NS34050/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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