| Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion. | |
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MedLine Citation:
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PMID: 9550507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The purpose of our study was to investigate the relationship between misery perfusion (increased oxygen extraction fraction, OEF) and baseline risk factors in patients with carotid occlusion. METHODS: One-hundred seventeen patients with atherosclerotic carotid occlusion were studied prospectively by clinical evaluation, laboratory testing, and positron emission tomography (PET). PET measurements of cerebral blood flow (CBF), cerebral blood volume (CBV), and OEF were made on enrollment in the study. Increased ipsilateral OEF was identified by comparison with 18 normal control subjects. Twenty-five baseline clinical, epidemiological, and arteriographic risk factors were assessed on study entry. Student t tests, chi(2) tests, and Fisher exact tests with Bonferroni correction were used to assess statistical significance (P<.05). RESULTS: Of 117 patients, 44 had increased OEF distal to the occluded carotid and 73 had normal OEFs. Thirty-nine of the 81 patients with prior ipsilateral ischemic symptoms had high OEFs (42%), whereas only 5 of the 31 asymptomatic patients had high OEFs (16%, P<.001). All of the other baseline risk factors were similar between the two groups of patients. CONCLUSIONS: Investigations of the relationship between hemodynamic factors and stroke risk must take into account the lower frequency of hemodynamic abnormalities in asymptomatic patients. |
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Authors:
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C P Derdeyn; K D Yundt; T O Videen; D A Carpenter; R L Grubb; W J Powers |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 29 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-05-01 Completed Date: 1998-05-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 754-8 Citation Subset: IM |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. derdeyn@mirlink.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arterial Occlusive Diseases / blood*, epidemiology Carotid Arteries / radiography Carotid Artery Diseases / blood*, epidemiology Hemodynamics / physiology* Homeostasis Humans Ischemic Attack, Transient / complications* Middle Aged Oxygen / blood* Oxygen Consumption* Prospective Studies Risk Factors Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS28947/NS/NINDS NIH HHS; NS34050/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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