Document Detail

Increased oxidative stress in patients with familial Mediterranean fever during attack period.
MedLine Citation:
PMID:  22135646     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to investigate the status of oxidant and antioxidants during attack period (AP) and attack free periods (AFP) in Familial Mediterranean fever (FMF) patients.
METHODS: Measured the levels of malondialdehyde (MDA), protein carbonyl (PC), glutathione (GSH) and antioxidant vitamins (A,C and E) as well as the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) in serum and whole blood of FMF patients in FMF-AP and FMF-AFP.
RESULTS: Levels of MDA and PC were found significantly higher (p <0.05) both in serum and whole blood of FMF-AP group compared with other groups. The CAT and GSH-Px activities in FMF-AP group were found markedly lower (p <0.05) comparing to HC group. However, there were no statistically significant differences between the groups in terms of antioxidant vitamin levels.
CONCLUSIONS: Our study demonstrated increased oxidative stress in patients with FMF during AP. Investigations are needed to establish the effect of antioxidant supplementation on FMF attack frequency and severity. We also suggest that these increased MDA and PC levels and decreased antioxidants may be used as supportive markers to differentiate AP from AFP. These conclusions need to be validated in further multicenter studies with high number of FMF patients.
L Ediz; H Ozkol; I Tekeoglu; Y Tuluce; E Gulcu; I Koyuncu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African health sciences     Volume:  11 Suppl 1     ISSN:  1729-0503     ISO Abbreviation:  Afr Health Sci     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-04-11     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101149451     Medline TA:  Afr Health Sci     Country:  Uganda    
Other Details:
Languages:  eng     Pagination:  S6-13     Citation Subset:  IM    
Yuzuncu Yil University, Medical Faculty, Physical Medicine-Rehabilitation and Rheumatology Department, Van, Turkey.
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MeSH Terms
Acute Disease
Familial Mediterranean Fever / blood,  metabolism*
Oxidative Stress / physiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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