Document Detail

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan.
MedLine Citation:
PMID:  18972548     Owner:  NLM     Status:  MEDLINE    
Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC.
Satoru Morimoto; Shigeki Kuzuhara; Yasumasa Kokubo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Department of Neurology, Mie University School of Medicine, Tsu, Japan.
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MeSH Terms
Aged, 80 and over
Amyotrophic Lateral Sclerosis / epidemiology,  metabolism*,  urine
Creatinine / therapeutic use
Endemic Diseases
Guanosine / analogs & derivatives,  urine
Japan / epidemiology
Oxidative Stress*
Parkinsonian Disorders / epidemiology,  metabolism*,  urine
Severity of Illness Index
Tauopathies / epidemiology,  metabolism*,  urine
Reg. No./Substance:
118-00-3/Guanosine; 3868-31-3/8-hydroxyguanosine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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