| Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan. | |
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MedLine Citation:
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PMID: 18972548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. |
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Authors:
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Satoru Morimoto; Shigeki Kuzuhara; Yasumasa Kokubo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 24 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mie University School of Medicine, Tsu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amyotrophic Lateral Sclerosis / epidemiology, metabolism*, urine Creatinine / therapeutic use Endemic Diseases Female Guanosine / analogs & derivatives, urine Humans Japan / epidemiology Male Oxidative Stress* Parkinsonian Disorders / epidemiology, metabolism*, urine Severity of Illness Index Tauopathies / epidemiology, metabolism*, urine |
| Chemical | |
Reg. No./Substance:
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118-00-3/Guanosine; 3868-31-3/8-hydroxyguanosine; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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