Document Detail


Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  16502343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An imbalance between oxidative stress and antioxidative capacity has been proposed to play an important role in the development and progression of chronic obstructive pulmonary disease. We carried out a study to assess the systemic oxidant-antioxidant status in patients with chronic obstructive pulmonary disease (COPD) and relate it to the severity of disease. We measured a wide range of parameters of oxidant-antioxidant balance in leukocytes, plasma and red cells of 82 patients with COPD and 22 healthy non-smoking controls (HNC). Lung function was measured by spirometry. Staging of COPD was done as per the recommended guidelines. Red cell antioxidative enzyme activities were altered, with glutathione peroxidase (GSH-Px) having lower, superoxide dismutase (SOD) having greater and catalase having similar activity in patients as compared to HNC. In plasma, ferric reducing antioxidant power (FRAP) and total protein sulfhydryls were lower and GSH-Px, lipid peroxides measured as MDA-TBA products, and protein carbonyls were higher in the patients as compared to HNC. Plasma total nitrates and nitrites (NO(x)) were similar in the two groups. Superoxide anion (O(2) (*-)) release from leukocytes upon stimulation with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and total blood glutathione were also higher in patients as compared to HNC. Plasma FRAP had a positive whereas total blood glutathione had a significant negative correlation with the severity of airways obstruction (FEV(1)% predicted). Further, comparisons between clinical stages of severity of COPD revealed significant differences in plasma FRAP and total blood glutathione. Our observations suggest there is a systemic oxidant-antioxidant imbalance in the patients with COPD.
Authors:
Ahmed Nadeem; Hanumanthrao Guru Raj; Sunil Kumar Chhabra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation     Volume:  29     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-32     Citation Subset:  IM    
Affiliation:
Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants / analysis*,  metabolism
Case-Control Studies
Catalase / blood
Erythrocytes / chemistry,  enzymology
Glutathione / blood
Glutathione Peroxidase / blood
Humans
Leukocytes / chemistry,  enzymology
Malondialdehyde / blood
Middle Aged
Oxidative Stress*
Pulmonary Disease, Chronic Obstructive / blood,  metabolism*
Reactive Oxygen Species / blood
Spirometry
Superoxide Dismutase / blood
Superoxides / blood
Thiobarbituric Acid Reactive Substances / analysis
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 11062-77-4/Superoxides; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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