| Increased oxidative stress and altered levels of antioxidants in asthma. | |
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MedLine Citation:
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PMID: 12532099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reactive oxygen species might play an important role in the modulation of airway inflammation. There is evidence of an oxidant-antioxidant imbalance in asthma. Although several oxidants and antioxidants are likely to be involved, alterations in only limited parameters have been studied in isolation. OBJECTIVE: We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidant-antioxidant imbalance. METHODS: In the peripheral blood of 38 patients with bronchial asthma and 23 control subjects, oxidative stress was measured in terms of superoxide anion generation by leukocytes, lipid peroxidation products, total nitrates and nitrites, total protein carbonyls, and total protein sulfhydrils in plasma. Antioxidant status was evaluated by measuring red blood cell superoxide dismutase and catalase activity, total blood glutathione, and glutathione peroxidase activity in red blood cells and leukocytes and total antioxidant capacity in plasma. RESULTS: Asthmatic patients showed increased superoxide generation from leukocytes, increased total nitrites and nitrates, increased protein carbonyls, and increased lipid peroxidation products and decreased protein sulfhydrils in plasma, indicating increased oxidative stress. They also showed increased superoxide dismutase activity in red blood cells and increased total blood glutathione and decreased glutathione peroxidase activity in red blood cells and leukocytes. Red blood cell catalase activity and the total antioxidant capacity of plasma were not altered. CONCLUSION: There are alterations in a wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in asthma. Therapeutic augmentation of the antioxidant defenses might be beneficial. |
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Authors:
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Ahmad Nadeem; Sunil K Chhabra; Anbrin Masood; Hanumanthrao G Raj |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 111 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-17 Completed Date: 2003-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 72-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Biochemistry, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antioxidants / metabolism* Asthma / metabolism* Erythrocytes / enzymology Female Humans Leukocytes / metabolism Lipid Peroxides / blood Male Nitrates / blood Nitrites / blood Oxidative Stress / physiology* Superoxide Dismutase / blood Superoxides / blood Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Lipid Peroxides; 0/Nitrates; 0/Nitrites; 0/Thiobarbituric Acid Reactive Substances; 11062-77-4/Superoxides; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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