| Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenon. | |
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MedLine Citation:
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PMID: 20670218 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: A significant increase in oesophageal acid exposure during early recumbent period has been demonstrated. AIM: To determine if acid reflux during the early recumbent period occurs in the recumbent-asleep or recumbent-awake period using a novel integrative actigraphy and pH programme. METHOD: Thirty-nine subjects with heartburn at least three times a week were included. Subjects underwent pH testing concomitantly with actigraphy. Simultaneously recorded actigraphy and pH data were incorporated using a novel integrative technique to determine sleep and awake periods. Characteristics of acid reflux were compared between the recumbent-awake and recumbent-asleep periods. RESULTS: Seventeen (44.7%) subjects had acid reflux events during recumbent-awake period as compared to seven (18.4%) in the corresponding recumbent-asleep period (P = 0.046). The mean number of acid reflux events in recumbent-awake period was significantly higher than in the corresponding recumbent-asleep period (8.1 +/- 4.4 vs. 3.2 +/- 1.5, P < 0.001). In the recumbent-awake period, 38.4% of acid reflux events were associated with GERD-related symptoms as compared with 3.7% of acid reflux events during the corresponding recumbent-asleep period (P = 0.01). CONCLUSION: Increased acid reflux in the early recumbent period occurs primarily during the recumbent-awake and not during the recumbent-asleep period. |
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Authors:
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L Allen; C H Poh; A Gasiorowska; I Malagon; T Navarro-Rodriguez; H Cui; J Powers; B Moty; M R Willis; N Ashpole; S F Quan; R Fass |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 32 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 787-94 Citation Subset: IM |
Copyright Information:
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2010 Blackwell Publishing Ltd. |
Affiliation:
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The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, AZ 85723-0001, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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