| Increased occurrence of pericardial effusion in patients with autosomal dominant polycystic kidney disease. | |
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MedLine Citation:
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PMID: 17928471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disease with prominent connective tissue manifestations. A frequent occurrence of asymptomatic pericardial effusion has been observed in patients with ADPKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive computed tomography scans from 60 patients with ADPKD (group 1), 100 patients without ADPKD and with serum creatinine concentration of > or = 1.1 mg/dl (group 2), and 100 potential kidney donors (group 3) were retrospectively examined. Pericardial effusion was graded from 0 to 4 on the basis of the distance between the parietal and visceral pericardia at mid, mid-low, and low levels of the heart on transaxial computed tomography scan sections. RESULTS: Twenty-one (35%) of 60 patients in group 1 were found to have pericardial effusion, compared with 9 (9%) and 4 (4%) patients in groups 2 and 3, respectively. Ten of the 21 patients with pericardial effusion in group 1 but none of the patients in groups 2 and 3 had moderate to high effusion scores. The presence and severity of pericardial effusion were not associated with age, renal dysfunction, or hypertension. All pericardial effusions were asymptomatic. CONCLUSIONS: Pericardial effusion occurs with an increased frequency in patients with ADPKD, possibly as a result of increased compliance of the parietal pericardium. Although frequently moderate to large, these effusions are generally well tolerated and clinically inconsequential. |
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Authors:
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Qi Qian; Robert P Hartman; Bernard F King; Vicente E Torres |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-10-10 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 2 ISSN: 1555-905X ISO Abbreviation: - Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-26 Completed Date: 2007-11-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1223-7 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. qian.qi@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antihypertensive Agents / therapeutic use Connective Tissue / physiology Extracellular Matrix / physiology Female Humans Hypertension / drug therapy, epidemiology Male Middle Aged Pericardial Effusion / epidemiology, etiology* Polycystic Kidney, Autosomal Dominant / complications* |
| Grant Support | |
ID/Acronym/Agency:
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DK073567/DK/NIDDK NIH HHS; DK63064/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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