Document Detail

Increased occurrence of pericardial effusion in patients with autosomal dominant polycystic kidney disease.
MedLine Citation:
PMID:  17928471     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disease with prominent connective tissue manifestations. A frequent occurrence of asymptomatic pericardial effusion has been observed in patients with ADPKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive computed tomography scans from 60 patients with ADPKD (group 1), 100 patients without ADPKD and with serum creatinine concentration of > or = 1.1 mg/dl (group 2), and 100 potential kidney donors (group 3) were retrospectively examined. Pericardial effusion was graded from 0 to 4 on the basis of the distance between the parietal and visceral pericardia at mid, mid-low, and low levels of the heart on transaxial computed tomography scan sections. RESULTS: Twenty-one (35%) of 60 patients in group 1 were found to have pericardial effusion, compared with 9 (9%) and 4 (4%) patients in groups 2 and 3, respectively. Ten of the 21 patients with pericardial effusion in group 1 but none of the patients in groups 2 and 3 had moderate to high effusion scores. The presence and severity of pericardial effusion were not associated with age, renal dysfunction, or hypertension. All pericardial effusions were asymptomatic. CONCLUSIONS: Pericardial effusion occurs with an increased frequency in patients with ADPKD, possibly as a result of increased compliance of the parietal pericardium. Although frequently moderate to large, these effusions are generally well tolerated and clinically inconsequential.
Qi Qian; Robert P Hartman; Bernard F King; Vicente E Torres
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-10-10
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  2     ISSN:  1555-905X     ISO Abbreviation:  -     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1223-7     Citation Subset:  IM    
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / therapeutic use
Connective Tissue / physiology
Extracellular Matrix / physiology
Hypertension / drug therapy,  epidemiology
Middle Aged
Pericardial Effusion / epidemiology,  etiology*
Polycystic Kidney, Autosomal Dominant / complications*
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents

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