Document Detail

Increased occurrence of marked elevations of lipoprotein(a) in ageing, hypercholesterolaemic men with low testosterone.
MedLine Citation:
PMID:  20059436     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We previously examined the inverse relationship between total serum testosterone (T) and the occurrence of the metabolic syndrome in ageing men using baseline data from two lipid treatment studies. We further examined baseline data from a subset of US men participating in one of these two studies to assess the relationship between T and the cardiovascular risk factor lipid, lipoprotein(a) [Lp(a)]. METHODS: Baseline T, lipid, glycaemic and anthropometric data were obtained from 107 men (mean age: 55 years). Inclusion criteria included low-density lipoprotein cholesterol > or = 3.4-4.9 mmol/l and triglycerides < or = 4.0 mmol/l. Baseline Lp(a) levels were examined across the following baseline T subgroups: <15 nmol/l (low/low-normal T) and > or = 15 nmol/l (normal T). RESULTS: There was an overall trend for a higher incidence of clinically significant Lp(a) elevations in men with low T; 17.1% of men in the low/low-normal T subgroup had an Lp(a) level > or = 3 times the upper limit of normal compared to 8.1% in the normal T subgroup. CONCLUSIONS: The data from this descriptive analysis suggest that ageing men with low serum T levels may have an increase in marked elevations in Lp(a), which would be expected to be associated with a significant increase in their cardiovascular event risk.
Steven A Kaplan; Jianxin Lin; Amy O Johnson-Levonas; Arvind K Shah; Alan G Meehan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The aging male : the official journal of the International Society for the Study of the Aging Male     Volume:  13     ISSN:  1473-0790     ISO Abbreviation:  Aging Male     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-12     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808210     Medline TA:  Aging Male     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-3     Citation Subset:  IM    
Weill Cornell Medical College, Institute for Bladder and Prostate Health, New York, NY 10021,USA.
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MeSH Terms
Aging / blood*
Cardiovascular Diseases / epidemiology*
Hypercholesterolemia / blood*
Lipoprotein(a) / blood*
Lipoproteins, LDL / blood
Metabolic Syndrome X / blood
Middle Aged
Testosterone / blood*
Triglycerides / blood
United States / epidemiology
Reg. No./Substance:
0/Lipoprotein(a); 0/Lipoproteins, LDL; 0/Triglycerides; 58-22-0/Testosterone

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