Document Detail

Increased occurrence of asthma and allergy: critical appraisal of studies using allergic sensitization, bronchial hyper-responsiveness and lung function measurements.
MedLine Citation:
PMID:  11678855     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many studies have reported an increase in the occurrence of asthma and respiratory allergies in recent decades, but this increase is mostly based on studies using rather subjective measurements of asthma and allergies, such as questionnaires and doctor's diagnosis. None of the reviews specifically focused on studies using more 'objective' measurements, such as sensitization (specific IgE or skin prick testing (SPT)), bronchial hyper-responsiveness (BHR) or lung function (LF). OBJECTIVE: To review articles studying a time trend of occurrence of these 'more objective' measurements. METHODS: A MEDLINE-search (1966-February 2000) was performed. The following criteria were used: population-based, using IgE, SPT, BHR or LF measurements in the same age-group at least twice, with at least 2 years between and using similar methods. RESULTS: The MEDLINE-search resulted in only 16 articles, performed in 13 populations in seven different countries. Nine articles used the same objective measurements twice in the whole population. Three of these reported a non-significant increase or decrease. The other six articles found a significant increase in at least one objective measurement and of these only three reported a consistent significant increase. CONCLUSIONS: The increase in the occurrence of reported asthma and allergy is supported by only a few articles confirming these results with 'more objective measurements'.
M H Wieringa; P A Vermeire; B Brunekreef; J J Weyler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  31     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-26     Completed Date:  2001-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1553-63     Citation Subset:  IM    
Department of Epidemiology and Community Medicine, University of Antwerp (UIA), Antwerp, Belgium.
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MeSH Terms
Antibody Specificity / immunology
Asthma / epidemiology*,  immunology,  physiopathology
Bronchial Hyperreactivity / complications,  immunology,  physiopathology
Child, Preschool
Great Britain / epidemiology
Hypersensitivity / epidemiology*,  immunology,  physiopathology
Immunoglobulin E / blood,  immunology
Japan / epidemiology
Lung / physiology
Middle Aged
Sensitivity and Specificity
Skin Tests
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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