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Increased number of Langerhans cells in oral lichen planus and oral lichenoid lesions.
MedLine Citation:
PMID:  22668625     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to quantify the presence of Langerhans cells (LC) in oral lichen planus (OLP) and oral lichenoid lesions (OLL), comparing them with normal epithelium.
STUDY DESIGN: Thirty-six patients with biopsy-proven OLP or OLL were selected for the study, as well as 23 control subjects free of inflammatory conditions. Immunohistochemical reactions were performed using the streptavidin-biotin peroxidase complex method with CD1a and CD83 primary antibodies. Densities were compared between groups and correlated with microscopic findings.
RESULTS: Patients with lichenoid conditions (OLP + OLL) presented higher densities of CD1a(+) cells than the control subjects (P = .03). Higher densities of CD1a were associated with a thinner layer of inflammatory cells (P = .02).
CONCLUSIONS: This study indicates that OLP and OLL are characterized by the recruitment of LC, which may play a significant role on its pathogenesis.
Authors:
Luiz Alcino Gueiros; Rogério Gondak; Jacks Jorge Júnior; Ricardo Della Coletta; Alessandra de Albuquerque Carvalho; Jair Carneiro Leão; Oslei Paes de Almeida; Pablo Agustin Vargas
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Publication Detail:
Type:  Journal Article     Date:  2012-04-12
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  113     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  661-6     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Oral Medicine Unit, Department of Clinics and Preventive Dentistry, Federal University of Pernambuco.
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