| Increased nuchal translucency thickness at 10-14 weeks of gestation as a predictor of severe twin-to-twin transfusion syndrome. | |
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MedLine Citation:
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PMID: 9286014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study examines a possible association between increased nuchal translucency thickness at 10-14 weeks of gestation in monochorionic twin pregnancies and the subsequent development of severe twin-to-twin transfusion syndrome (TTS). In 132 monochorionic twin pregnancies, including 16 that developed severe TTS at 15-22 weeks of gestation and 116 that did not develop TTS, crown-rump length, nuchal translucency thickness and fetal heart rate were measured at 10-14 weeks. In those that developed severe TTS, the prevalence of nuchal translucency thickness above the 95th centile of the normal range and the intertwin difference in nuchal translucency thickness and fetal heart rate were significantly higher than in the non-TTS group; there were no significant differences between the groups in the inter-twin difference in crown-rump length. For fetal nuchal translucency above the 95th centile, the positive and negative predictive values for the development of TTS were 38% and 91%, respectively; the likelihood ratios of nuchal translucency above or below the 95th centile for the development of severe TTS were 4.4 (1.8-9.7) and 0.7 (0.4-0.9), respectively. These findings demonstrate that the underlying hemodynamic changes associated with TTS may manifest as increased fetal nuchal translucency thickness at 10-14 weeks of gestation. |
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Authors:
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N J Sebire; C D'Ercole; K Hughes; M Carvalho; K H Nicolaides |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 10 ISSN: 0960-7692 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-10-16 Completed Date: 1997-10-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 86-9 Citation Subset: IM |
Affiliation:
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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorion / ultrasonography Crown-Rump Length Female Fetofetal Transfusion / physiopathology, ultrasonography* Gestational Age Heart Rate, Fetal Humans Neck / ultrasonography* Predictive Value of Tests Pregnancy Pregnancy Trimester, First Pregnancy, Multiple Retrospective Studies Twins* Ultrasonography, Prenatal* |
| Comments/Corrections | |
Comment In:
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Ultrasound Obstet Gynecol. 1997 Aug;10(2):82-5
[PMID:
9286013
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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