| Increased nuchal translucency in euploid fetuses--what should we be telling the parents? | |
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MedLine Citation:
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PMID: 20077440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nuchal translucency (NT) measurement between 11 and 14 weeks' gestation is an undisputed marker for aneuploidies. When conventional karyotyping is normal, enlarged NT is a strong marker for adverse pregnancy outcome, associated with miscarriage, intrauterine death, congenital heart defects, and numerous other structural defects and genetic syndromes. The risk of adverse outcome is proportional to the degree of NT enlargement. Although the majority of structural anomalies are amenable to ultrasound detection, unspecified genetic syndromes involving developmental delay may only emerge after birth. Concern over these prenatally undetectable conditions is a heavy burden for parents. However, following detection of enlarged NT the majority of babies with normal detailed ultrasound examination and echocardiography will have an uneventful outcome with no increased risk for developmental delay when compared to the general population. Counseling should emphasize this to help parents restore hope in normal pregnancy outcome and infant development. |
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Authors:
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C M Bilardo; E Timmerman; E Pajkrt; M van Maarle |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 93-102 Citation Subset: IM |
Copyright Information:
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(c) 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics and Gynaecology, Fetal Medicine Unit Academic Medical Centre, Amsterdam, The Netherlands. c.m.bilardo@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy* Female Fetal Diseases / diagnosis*, ultrasonography Genetic Counseling* Gestational Age Humans Karyotyping Nuchal Translucency Measurement* Pregnancy Pregnancy Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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