Document Detail


Increased nuchal translucency and congenital heart disease.
MedLine Citation:
PMID:  22482746     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sonographic assessment of fetal nuchal translucency (NT) thickness is the cornerstone of screening for chromosomal abnormality at 11-13(+6)weeks gestation. This marker was first recognized in pregnancies being karyotyped for advanced maternal age, but its underlying pathophysiology remains to be fully determined. Although increased NT is clearly associated with changes in both lymphatic and cardiac development, neither is an obvious causative agent. The association with cardiac defects has now being subjected to a significant amount of research, with a large body of evidence showing that this marker is also a screening tool for major cardiac defects - although it performs more modestly than for chromosomal abnormality. The field continues to change rapidly. Recent evidence that uses a combination of increased NT, tricuspid regurgitation and abnormal flow in the 'a' wave of the ductus venosus can provide an effective screening strategy to predict many major cardiac defects at this early stage of pregnancy.
Authors:
Ritu Mogra; Nasser Alabbad; Jon Hyett
Related Documents :
11559906 - First-trimester maternal serum human thyroid-stimulating hormone in chromosomally norma...
8373526 - Low periconceptional maternal serum thymosin alpha 1 levels are associated with blighte...
9756316 - Evaluation of serum inhibin a as a surveillance marker after conservative management of...
8421106 - Increased in vitro thyrotropic activity of partially sialated human chorionic gonadotro...
8596256 - Pregnancy, abortion, and birth rates among us adolescents--1980, 1985, and 1990.
18221926 - Alternative complement pathway activation fragment bb in early pregnancy as a predictor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Discipline of Obstetrics and Gynaecology, Central Clinical School, Faculty of Medicine, University of Sydney, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ultra-high Sensitive Piezotronic Strain Sensors Based on ZnSnO3 Nanowire/Microwire.
Next Document:  Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana.