Document Detail

Increased nosocomial infection in neutropenic low birth weight (2000 grams or less) infants of hypertensive mothers.
MedLine Citation:
PMID:  1447666     Owner:  NLM     Status:  MEDLINE    
The neutropenia often seen in infants of hypertensive mothers (IHMs) at < 12 hours of age has been associated with nosocomial infection in the first 18 days of life. To assess maternal hypertension as an independent factor for nosocomial infection, we compared 101 low birth weight (< or = 2.00 kg) IHMs to a concurrent birth weight-matched group of infants of normotensive mothers (INMs). Infants without differential leukocyte counts at < 12 hours of age were excluded, leaving 93 IHMs and 98 INMs. The incidence of neutropenia at < 12 hours among IHMs was not significantly different from that among INMs (42/92 (45%) vs 37/98 (38%)). Nosocomial infection was more frequent in neutropenic IHMs than in neutropenic INMs (12/42 vs 2/37; p = 0.007). Infection in IHMs included omphalitis (2 infants), pneumonia (4), and sepsis with or without meningitis (6); INMs had cellulitis (1) and sepsis (1). The underlying mechanism(s) for this predisposition remains to be elucidated, although limited data suggest that neutropenia may be more severe and prolonged among IHMs.
M Cadnapaphornchai; R G Faix
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  121     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-30     Completed Date:  1992-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  956-61     Citation Subset:  AIM; IM    
Department of Pediatrics and Communicable Diseases, University of Michigan Medical Center, Ann Arbor.
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MeSH Terms
Chi-Square Distribution
Cross Infection / epidemiology*
Hypertension / epidemiology*
Infant, Low Birth Weight*
Infant, Newborn
Leukocyte Count
Michigan / epidemiology
Neutropenia / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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