| Increased non-collagen protein synthesis in the posterior cerebral artery in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 3097282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When 3H-proline was administered to spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats, its incorporation into non-collagen protein of the posterior cerebral artery or the mesenteric artery was greater in SHR than WKY. Young SHR were treated with either clonidine or 6-hydroxydopamine (6-OHDA). Administration of clonidine decreased the rate of incorporation of 3H-proline into the non-collagen protein of these arteries concomitantly with a reduction of blood pressure in each rat strain. Administration of 6-OHDA slightly decreased the incorporation of the proline into the non-collagen protein of the SHR posterior cerebral artery, but failed to reduce blood pressure in each rat strain. Ultrastructural pictures of the posterior cerebral arteries of the SHR showed numerous adrenergic ganglion cells. Thus, neural factors, especially in the cerebral arteries, may regulate vascular protein synthesis and may be important for the initiation of hypertension in SHR. |
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Authors:
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T Nakada; M Kimura; H Watanabe; Y Yamori; W Lovenberg |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 4 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-23 Completed Date: 1986-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S93-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Arteries / metabolism* Clonidine / pharmacology Hydroxydopamines / pharmacology Hypertension / genetics*, metabolism Male Oxidopamine Proline / metabolism Protein Biosynthesis Rats Rats, Inbred SHR / metabolism* Rats, Inbred Strains / metabolism* Rats, Inbred WKY Sympathetic Nervous System / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxydopamines; 1199-18-4/Oxidopamine; 147-85-3/Proline; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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