| Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty. | |
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MedLine Citation:
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PMID: 7608268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypogonadotropic hypogonadism (IGD) and constitutional delayed puberty (DP) share a common pathophysiologic process, i.e. GnRH deficiency. Both conditions are heterogenous and exhibit different grades of GnRH deficiency. To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles, we compared untreated young males IGD (n = 7) and DP (n = 7) to normal pubertal male controls (n = 6). Serum samples for melatonin, LH, and prolactin concentrations were obtained every 15 min from 1900 h to 0700 h in a controlled light-dark environment with simultaneous sleep recordings. Mean (+/- SD) darktime nocturnal melatonin levels were significantly higher in IGD (259 +/- 73 pmol/L) and DP (217 +/- 29 pmol/L) compared with 182 +/- 69 pmol/L in controls (P < 0.02). So were the mean (+/- SD) peak melatonin levels (410 +/- 117, 327 +/- 97 and 298 +/- 95 pmol/L in IGD, DP, and controls, respectively (P < 0.05). Integrated nocturnal melatonin secretion values (AUC) were also higher in IGD and DP (168 +/- 45 and 134 +/- 28) compared with 119 +/- 45 pmol/min.1 x 10(3) in controls (P < 0.02). The time of melatonin peak and the time of onset of the nocturnal melatonin rise were observed earlier in IGD and DP. Light-time mean (+/- SD) serum melatonin levels were similar in all three groups. No correlations were found between melatonin and LH levels, nor between melatonin and prolactin levels. These data indicate that melatonin secretion is increased in male patients with GnRH deficiency. The lack of correlations between melatonin and LH suggest that circulating sex steroids, rather than LH, modulate melatonin secretion in a reverse fashion. |
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Authors:
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R Luboshitzky; S Lavi; I Thuma; P Lavie |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 80 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-08-11 Completed Date: 1995-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2144-8 Citation Subset: AIM; IM |
Affiliation:
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Endocrine Institute, Central Emek Hospital, Afula, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activity Cycles* Adolescent Cohort Studies Dehydroepiandrosterone / analogs & derivatives, blood Dehydroepiandrosterone Sulfate Gonadotropin-Releasing Hormone / diagnostic use Humans Hydrocortisone / blood Hypogonadism / blood*, physiopathology Luteinizing Hormone / blood, secretion* Male Melatonin / blood, secretion* Prolactin / blood, secretion Puberty, Delayed / blood*, physiopathology Reference Values Testis / anatomy & histology* Testosterone / blood Thyrotropin-Releasing Hormone / diagnostic use |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 33515-09-2/Gonadotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 73-31-4/Melatonin; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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