| Increased nanog expression promotes tumor development and Cisplatin resistance in human esophageal cancer cells. | |
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MedLine Citation:
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PMID: 23221432 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/Aims: Nanog plays a key role in stem cell self-renewal and pluripotency differentiation in embryonic stem cells ( ESCs). Recently, some studies reported that abnormal expression of Nanog could be detected in several tumors, indicating that Nanog might be related to tumor development. However, studies on the correlation between Nanog expression and esophageal cancer are sparse. Methods: In this study, we established two esophageal cancer cell lines 9706-Nanog and 9706-shNanog which stably expressed Nanog and Nanog-short-hairpin RNA (shRNA) genes. Results: We found that Nanog expression could promote the proliferation and invasiveness of the cancer cells, and inhibit the apoptosis. We also treated 9706-Nanog, EC9706 and 9706-shNanog cell lines with cisplatin and evaluated the drug sensitivity of the three cell lines. We found that the sensitivity of cisplatin was decreased with increased expression of Nanog. The expression of MDR-1 was also increased in 9706Nanog cells. Conclusions: Nanog may play an important role in human esophageal cancer development, and could be used as a therapeutic target in esophageal cancer treatment. |
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Authors:
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Li Yang; Xudong Zhang; Mingzhi Zhang; Junhui Zhang; Yuqiao Sheng; Xiangdong Sun; Qingjiang Chen; Le-Xin Wang |
Publication Detail:
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Type: Journal Article Date: 2012-09-12 |
Journal Detail:
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Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Volume: 30 ISSN: 1421-9778 ISO Abbreviation: Cell. Physiol. Biochem. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9113221 Medline TA: Cell Physiol Biochem Country: Switzerland |
Other Details:
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Languages: eng Pagination: 943-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Departments of Reproductive Medicine Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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