Document Detail

Increased nanog expression promotes tumor development and Cisplatin resistance in human esophageal cancer cells.
MedLine Citation:
PMID:  23221432     Owner:  NLM     Status:  In-Data-Review    
Background/Aims: Nanog plays a key role in stem cell self-renewal and pluripotency differentiation in embryonic stem cells ( ESCs). Recently, some studies reported that abnormal expression of Nanog could be detected in several tumors, indicating that Nanog might be related to tumor development. However, studies on the correlation between Nanog expression and esophageal cancer are sparse. Methods: In this study, we established two esophageal cancer cell lines 9706-Nanog and 9706-shNanog which stably expressed Nanog and Nanog-short-hairpin RNA (shRNA) genes. Results: We found that Nanog expression could promote the proliferation and invasiveness of the cancer cells, and inhibit the apoptosis. We also treated 9706-Nanog, EC9706 and 9706-shNanog cell lines with cisplatin and evaluated the drug sensitivity of the three cell lines. We found that the sensitivity of cisplatin was decreased with increased expression of Nanog. The expression of MDR-1 was also increased in 9706Nanog cells. Conclusions: Nanog may play an important role in human esophageal cancer development, and could be used as a therapeutic target in esophageal cancer treatment.
Li Yang; Xudong Zhang; Mingzhi Zhang; Junhui Zhang; Yuqiao Sheng; Xiangdong Sun; Qingjiang Chen; Le-Xin Wang
Publication Detail:
Type:  Journal Article     Date:  2012-09-12
Journal Detail:
Title:  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology     Volume:  30     ISSN:  1421-9778     ISO Abbreviation:  Cell. Physiol. Biochem.     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9113221     Medline TA:  Cell Physiol Biochem     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  943-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Departments of Reproductive Medicine Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, P.R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cel...
Next Document:  Flexible cystoscope for evaluating pelvic fracture urethral distraction defects.