| Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease. | |
MedLine Citation:
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PMID: 20626583 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury. Aims: To determine myocardial methionine-enkephalin content in children with hypoxemic congenital heart defects and to correlate myocardial content of methionine-enkephalin with the extent of arterial oxygen desaturation. Methods: Children (n = 20, median age of 16 months), undergoing cardiac surgical repair (tetralogy of Fallot, 17/20), were included in this study. Arterial oxygen saturation was measured on admission. Myocardial samples obtained during surgery were assayed via radioimmunochemistry for methionine-enkephalin content. Results: Greater methionine-enkephalin content was measured in the right ventricles of the patients suffering from recent cyanotic spells compared with those with no recent spells (cyanotic spells: 2418 +/- 844 pg/g wet weight tissue, n = 6; no spells: 1175 +/- 189 pg/g wet weight tissue, n = 14, P = 0.04). An inverse correlation was evident between the arterial oxygen saturation and myocardial methionine-enkephalin content. Conclusion: Myocardial methionine-enkephalin levels increase with the severity of hypoxic stress in congenital cardiac disease and may play an important adaptive role in countering adrenergic over-activity and related excess demand on myocardial metabolic capacity. |
Authors:
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Olivier Wv van den Brink; Andrew D Cochrane; Franklin L Rosenfeldt; Daniel J Penny; Salvatore Pepe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-7-07 |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: - ISSN: 1440-1754 ISO Abbreviation: - Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-7-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiothoracic Surgery, Alfred Hospital,University of Melbourne, Melbourne, Victoria, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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