Document Detail

Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease.
MedLine Citation:
PMID:  20626583     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND:   Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury.
AIMS:   To determine myocardial methionine-enkephalin content in children with hypoxemic congenital heart defects and to correlate myocardial content of methionine-enkephalin with the extent of arterial oxygen desaturation.
METHODS:   Children (n= 20, median age of 16 months), undergoing cardiac surgical repair (tetralogy of Fallot, 17/20), were included in this study. Arterial oxygen saturation was measured on admission. Myocardial samples obtained during surgery were assayed via radioimmunochemistry for methionine-enkephalin content.
RESULTS:   Greater methionine-enkephalin content was measured in the right ventricles of the patients suffering from recent cyanotic spells compared with those with no recent spells (cyanotic spells: 2418 ± 844 pg/g wet weight tissue, n= 6; no spells: 1175 ± 189 pg/g wet weight tissue, n= 14, P= 0.04). An inverse correlation was evident between the arterial oxygen saturation and myocardial methionine-enkephalin content.
CONCLUSION:   Myocardial methionine-enkephalin levels increase with the severity of hypoxic stress in congenital cardiac disease and may play an important adaptive role in countering adrenergic over-activity and related excess demand on myocardial metabolic capacity.
Olivier Wv van den Brink; Andrew D Cochrane; Franklin L Rosenfeldt; Daniel J Penny; Salvatore Pepe
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Publication Detail:
Type:  Journal Article     Date:  2010-07-07
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  50     ISSN:  1440-1754     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  E63-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
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