Document Detail


Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease.
MedLine Citation:
PMID:  20626583     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury. Aims: To determine myocardial methionine-enkephalin content in children with hypoxemic congenital heart defects and to correlate myocardial content of methionine-enkephalin with the extent of arterial oxygen desaturation. Methods: Children (n = 20, median age of 16 months), undergoing cardiac surgical repair (tetralogy of Fallot, 17/20), were included in this study. Arterial oxygen saturation was measured on admission. Myocardial samples obtained during surgery were assayed via radioimmunochemistry for methionine-enkephalin content. Results: Greater methionine-enkephalin content was measured in the right ventricles of the patients suffering from recent cyanotic spells compared with those with no recent spells (cyanotic spells: 2418 +/- 844 pg/g wet weight tissue, n = 6; no spells: 1175 +/- 189 pg/g wet weight tissue, n = 14, P = 0.04). An inverse correlation was evident between the arterial oxygen saturation and myocardial methionine-enkephalin content. Conclusion: Myocardial methionine-enkephalin levels increase with the severity of hypoxic stress in congenital cardiac disease and may play an important adaptive role in countering adrenergic over-activity and related excess demand on myocardial metabolic capacity.
Authors:
Olivier Wv van den Brink; Andrew D Cochrane; Franklin L Rosenfeldt; Daniel J Penny; Salvatore Pepe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-7-07
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  -     ISSN:  1440-1754     ISO Abbreviation:  -     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-7-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiothoracic Surgery, Alfred Hospital,University of Melbourne, Melbourne, Victoria, Australia.
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