Document Detail

Increased muscularization of small pulmonary arteries in preterm infants of diabetic mothers: a morphometric study in noninflated, noninjected, routinely fixed lungs.
MedLine Citation:
PMID:  8597856     Owner:  NLM     Status:  MEDLINE    
We attempted to identify a structural correlate of the pulmonary hypertension observed in newborn infants of diabetic mothers (IDM) by performing a morphometric analysis of pulmonary arteries at the transition of terminal to respiratory bronchiolus (TRB) in postmortem lungs of 20 IDM and 14 control infants. Although there was no readily apparent microscopic difference between the lungs of newborn IDM and controls, the degree of muscularization, as measured by mean medial area (MMA) of 10 TRB arteries, was significantly greater in preterm IDM (gestational age < or = 37 weeks) than in age-matched controls (502 versus 341 microns 2; P = .0038). Among infants of gestational age > 37 weeks, there was no significant difference between MMA in IDM (508 microns 2) and MMA in controls (598 microns 2). These findings point at an accelerated muscularization of the TRB arteries in IDM, apparent early in the third trimester. The pathogenesis of this hypermuscularization is not understood, but smooth muscle growth promoters such as insulin may play a role. The abnormal timing of TRB artery muscularization could be a manifestation of the basic disturbance in development that contributes to the pulmonary hypertension observed in newborn IDM and to the respiratory difficulties commonly experienced by these infants.
C Colpaert; J Hogan; A R Stark; D R Genest; D Roberts; L Reid; H Kozakewich
Related Documents :
6744566 - Results of the senning operation for transposition of the great arteries with intact ve...
15763296 - Congenital lobar emphysema: an otolaryngologic perspective.
12605006 - The use of pulmonary interstitial emphysema as an indicator of live birth.
2976816 - Drug-induced paralysis (muscle relaxant) therapy in the mechanically ventilated neonate.
14672496 - Acog committee opinion. use of progesterone to reduce preterm birth.
15192906 - Multiple-race mortality data for california, 2000-2001.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association     Volume:  15     ISSN:  1077-1042     ISO Abbreviation:  Pediatr Pathol Lab Med     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-04-22     Completed Date:  1996-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9518033     Medline TA:  Pediatr Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-705     Citation Subset:  IM    
Department of Pathology, Children's Hospital, Boston, Massachusetts 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchi / blood supply,  pathology
Collagen / chemistry
Hypertension, Pulmonary / etiology,  pathology*
Infant, Newborn
Infant, Premature, Diseases / etiology,  pathology*
Lung / pathology
Muscle, Smooth, Vascular / pathology*
Myocardium / pathology
Pregnancy in Diabetics*
Pulmonary Alveoli / pathology
Pulmonary Artery / pathology*
Tissue Fixation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Good prognosis of cellular mesoblastic nephroma with hyperdiploidy and relaxation of imprinting of t...
Next Document:  Immunohistologic quantification of Pseudomonas aeruginosa in the tracheobronchial tree from patients...