Document Detail


Increased muscularization of small pulmonary arteries in preterm infants of diabetic mothers: a morphometric study in noninflated, noninjected, routinely fixed lungs.
MedLine Citation:
PMID:  8597856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We attempted to identify a structural correlate of the pulmonary hypertension observed in newborn infants of diabetic mothers (IDM) by performing a morphometric analysis of pulmonary arteries at the transition of terminal to respiratory bronchiolus (TRB) in postmortem lungs of 20 IDM and 14 control infants. Although there was no readily apparent microscopic difference between the lungs of newborn IDM and controls, the degree of muscularization, as measured by mean medial area (MMA) of 10 TRB arteries, was significantly greater in preterm IDM (gestational age < or = 37 weeks) than in age-matched controls (502 versus 341 microns 2; P = .0038). Among infants of gestational age > 37 weeks, there was no significant difference between MMA in IDM (508 microns 2) and MMA in controls (598 microns 2). These findings point at an accelerated muscularization of the TRB arteries in IDM, apparent early in the third trimester. The pathogenesis of this hypermuscularization is not understood, but smooth muscle growth promoters such as insulin may play a role. The abnormal timing of TRB artery muscularization could be a manifestation of the basic disturbance in development that contributes to the pulmonary hypertension observed in newborn IDM and to the respiratory difficulties commonly experienced by these infants.
Authors:
C Colpaert; J Hogan; A R Stark; D R Genest; D Roberts; L Reid; H Kozakewich
Related Documents :
2976816 - Drug-induced paralysis (muscle relaxant) therapy in the mechanically ventilated neonate.
7076436 - Radiographic chest contour and pulmonary air leaks in oligohydramnios-related pulmonary...
20172666 - Functional echocardiography; from physiology to treatment.
10535826 - Reduced frequency of occlusion of aorto-pulmonary shunts in infants receiving aspirin.
9176836 - Abnormal thyroid function tests in infants with congenital hypothyroidism: the influenc...
23450546 - Nasal versus oral route for placing feeding tubes in preterm or low birth weight infants.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association     Volume:  15     ISSN:  1077-1042     ISO Abbreviation:  Pediatr Pathol Lab Med     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-04-22     Completed Date:  1996-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9518033     Medline TA:  Pediatr Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-705     Citation Subset:  IM    
Affiliation:
Department of Pathology, Children's Hospital, Boston, Massachusetts 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bronchi / blood supply,  pathology
Collagen / chemistry
Female
Humans
Hypertension, Pulmonary / etiology,  pathology*
Infant, Newborn
Infant, Premature, Diseases / etiology,  pathology*
Lung / pathology
Male
Muscle, Smooth, Vascular / pathology*
Myocardium / pathology
Pregnancy
Pregnancy in Diabetics*
Pulmonary Alveoli / pathology
Pulmonary Artery / pathology*
Tissue Fixation
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Good prognosis of cellular mesoblastic nephroma with hyperdiploidy and relaxation of imprinting of t...
Next Document:  Immunohistologic quantification of Pseudomonas aeruginosa in the tracheobronchial tree from patients...