Document Detail


Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats.
MedLine Citation:
PMID:  21285401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to assess the effects of dehydroepiandrosterone (DHEA) administration and exercise training on muscular DHEA and 5α-dihydrotestosterone (DHT) levels and hyperglycemia in diet-induced obese and hyperglycemic rats. After 14 wk of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of three 6-wk regimens: control, DHEA treatment, or exercise training (running at 25 m/min for 1 h, 5 days/wk; n = 10 each group). Results indicate that either 6 wk of DHEA treatment or exercise training significantly attenuated serum insulin and fasting glucose levels compared with the control group. Plasma and muscle concentrations of DHEA and DHT and expression levels of 5α-reductase were significantly higher in the DHEA-treated and exercise-training groups. Moreover, both DHEA administration and exercise training upregulated GLUT4 translocation with concomitant increases in protein kinase B and protein kinase Cζ/λ phosphorylation. Muscle DHEA and DHT concentrations closely correlated with blood glucose levels (DHEA treatment: r = -0.68, P < 0.001; exercise training: r = -0.65, P < 0.001), serum insulin levels, and activation of the GLUT4-regulated signaling pathway. Thus, increased levels of muscle sex steroids may contribute to improved fasting glucose levels via upregulation of GLUT4-regulated signaling in diet-induced obesity and hyperglycemia.
Authors:
Koji Sato; Motoyuki Iemitsu; Katsuji Aizawa; Noboru Mesaki; Satoshi Fujita
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-01
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  301     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-09-30     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E274-80     Citation Subset:  IM    
Affiliation:
Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Body Weight / drug effects,  physiology
Cholestenone 5 alpha-Reductase / metabolism
Dehydroepiandrosterone / metabolism,  pharmacology*
Dietary Sucrose / pharmacology
Dihydrotestosterone / metabolism*
Glucose Transporter Type 4 / metabolism
Hyperglycemia / drug therapy*,  metabolism*
Isoenzymes / metabolism
Male
Obesity / drug therapy,  metabolism
Physical Conditioning, Animal / physiology*
Protein Kinase C / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Rats
Rats, Wistar
Signal Transduction / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Sucrose; 0/Glucose Transporter Type 4; 0/Isoenzymes; 0/Slc2a4 protein, rat; 521-18-6/Dihydrotestosterone; 53-43-0/Dehydroepiandrosterone; EC 1.3.1.22/Cholestenone 5 alpha-Reductase; EC 2.7.11.1/Akt1 protein, rat; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/protein kinase C zeta; EC 2.7.11.13/Protein Kinase C; EC 2.7.11.13/protein kinase C lambda

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