| Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats. | |
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MedLine Citation:
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PMID: 21285401 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study was undertaken to assess the effects of DHEA administration and exercise training on muscular DHEA and DHT levels and hyperglycemia in diet-induced obese and hyperglycemic rats. After 14 weeks of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of three 6-week regimens: control, obese DHEA treatment or obese exercise training (running at 25 m/min for 1 hour, 5 days/week) (n = 10 each group). The results indicate that either 6 weeks of DHEA treatment or exercise training significantly attenuated serum insulin and fasting glucose levels compared with the control group. Plasma and muscle concentrations of DHEA and DHT, and expression levels of 5α-reductase were significantly higher in the obese DHEA-treated and exercise-training groups. Moreover, both DHEA administration and exercise training upregulated GLUT4 translocation with concomitant increases in protein kinase B and protein kinase C-ζ/λ phosphorylation. Muscle DHEA and DHT concentrations closely correlated with blood glucose levels (DHEA treatment: r= -0.68, P < 0.001; exercise training: r= -0.65, P < 0.001), serum insulin levels, and activation of the GLUT4 regulated signaling pathway. Thus, it is speculated that increased levels of muscle sex steroids may contribute to improved fasting glucose levels via upregulation of GLUT4 regulated signaling in diet-induced obesity and hyperglycemia. |
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Authors:
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Koji Sato; Motoyuki Iemitsu; Katsuji Aizawa; Noboru Mesaki; Satoshi Fujita |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Ritsumeikan University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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