Document Detail


Increased mortality in COPD among construction workers exposed to inorganic dust.
MedLine Citation:
PMID:  15065829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to find out if occupational exposure to dust, fumes or gases, especially among never-smokers, increased the mortality from chronic obstructive pulmonary disease (COPD). A cohort of 317,629 Swedish male construction workers was followed from 1971 to 1999. Exposure to inorganic dust (asbestos, man-made mineral fibres, dust from cement, concrete and quartz), gases and irritants (epoxy resins, isocyanates and organic solvents), fumes (asphalt fumes, diesel exhaust and metal fumes), and wood dust was based on a job-exposure matrix. An internal control group with "unexposed" construction workers was used, and the analyses were adjusted for age and smoking. When all subjects were analysed, there was an increased mortality from COPD among those with any airborne exposure (relative risk 1.12 (95% confidence interval (CI) 1.03-1.22)). In a Poisson regression model, including smoking, age and the major exposure groups, exposure to inorganic dust was associated with an increased risk (hazard ratio (HR) 1.10 (95% CI 1.06-1.14)), especially among never-smokers (HR 2.30 (95% CI 1.07-4.96)). The fraction of COPD among the exposed attributable to any airborne exposure was estimated as 10.7% overall and 52.6% among never-smokers. In conclusion, occupational exposure among construction workers increases mortality due to chronic obstructive pulmonary disease, even among never-smokers.
Authors:
I A Bergdahl; K Torén; K Eriksson; U Hedlund; T Nilsson; R Flodin; B Järvholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  23     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-06-17     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  402-6     Citation Subset:  IM    
Affiliation:
Occupational Medicine, Dept of Clinical Medicine and Public Health, Umeå University, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Construction Materials*
Dust*
Humans
Male
Middle Aged
Occupational Diseases / mortality*
Occupational Exposure / adverse effects*
Occupations
Pulmonary Disease, Chronic Obstructive / mortality*
Risk
Smoking
Time Factors
Chemical
Reg. No./Substance:
0/Dust
Comments/Corrections
Comment In:
Eur Respir J. 2004 Sep;24(3):512; author reoly 512   [PMID:  15358715 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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