Document Detail

Increased mole fraction of arachidonic acid in bronchial phospholipids in patients with cystic fibrosis.
MedLine Citation:
PMID:  3775237     Owner:  NLM     Status:  MEDLINE    
The fatty acid pattern of the phospholipids in the bronchial secretion of patients with cystic fibrosis (CF) showed an increase of the mole fraction of arachidonic acid (AA) in most phospholipid classes compared to normals. Increase of AA in some classes was also found in patients with chronic bronchitis and in patients chronically colonized with Pseudomonas aeruginosa but in the diphosphatidylglycerol, lysophosphatidylethanolamine and sphingomyelin phospholipids, high fractions of AA was found exclusively in CF patients. Arachidonic acid was found to attain the highest ratios in CF in seven of the nine major bronchial phospholipids compared to the controls. There was no difference in the ratio saturated/unsaturated fatty acids between the CF patients and the control groups. A tendency towards unsaturation of the fatty acids in the bronchial secretion seems to be characteristic of infection and inflammation but AA appears to be more markedly increased in CF. Thus, the recorded changes may be characteristic for CF and not secondary to infection and/or inflammation in general, nor to P. aeruginosa colonization.
H Gilljam; B Strandvik; A Ellin; L G Wiman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  46     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-25     Completed Date:  1986-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-8     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / analysis*
Bronchi / secretion*
Bronchitis / metabolism
Cystic Fibrosis / metabolism*,  microbiology
Hydrogen-Ion Concentration
Phospholipids / analysis*,  secretion
Reg. No./Substance:
0/Arachidonic Acids; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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