Document Detail

Increased mineral dust-induced production of reactive oxygen species by blood monocytes from patients with malignant diseases.
MedLine Citation:
PMID:  7826606     Owner:  NLM     Status:  MEDLINE    
Mononuclear leukocytes were isolated from the peripheral blood of 15 patients with malignant pulmonary diseases, 17 patients with pulmonary infections, 18 patients with chest film abnormalities of non-malignant, non-infectious etiology, and 15 healthy persons. The cells were exposed to zymosan yeast, BCG vaccine, quartz, or chrysotile asbestos, and the subsequent production of reactive oxygen species (ROS) was measured by luminol-dependent chemiluminescence. All the stimulants caused significantly higher ROS production in the patient groups than in the healthy control group, and the asbestos-induced ROS production was significantly more pronounced in the cancer group than in the two non-cancer patient groups combined. After one-year follow-up, 5 of the 15 cancer patients were alive, and these patients had significantly lower mineral dust-induced ROS responses at the time of diagnosis than were found in the patients who died. This result was verified in a subsequent study comprising 19 patients with malignant pulmonary disorders (6 alive after one year). In conclusion, monocytes from patients with malignant diseases seem to be primed for an increased ROS production, and high ROS responses seem to correlate with a poor one-year survival of the patients.
P W Nyberg; S A Nordman; M L Klockars
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  102     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  765-70     Citation Subset:  IM    
Mjölbolsta Hospital, Finland.
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MeSH Terms
Asbestos, Serpentine / pharmacology
BCG Vaccine / pharmacology
Cells, Cultured
Chemiluminescent Measurements
Follow-Up Studies
Lung Diseases / blood*,  mortality
Lung Neoplasms / blood*,  mortality
Middle Aged
Monocytes / drug effects,  metabolism*,  pathology
Quartz / pharmacology
Reactive Oxygen Species / analysis*
Survival Analysis
Zymosan / pharmacology
Reg. No./Substance:
0/Asbestos, Serpentine; 0/BCG Vaccine; 0/Dust; 0/Reactive Oxygen Species; 14808-60-7/Quartz; 9010-72-4/Zymosan

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