| Increased migration of a human glioma cell line after in vitro Cyberknife irradiation. | |
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MedLine Citation:
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PMID: 21775821 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A human glioblastoma multiforme cell line (U87) and its derived-spheroids were irradiated either using a conventional irradiation (CIR) or a CK-like irradiation (IIR) in which the 8Gy was delivered intermittently over a period of 40 minutes. The ability of glioma cells to migrate into a matrigel matrix was evaluated on days 1-8 from irradiation. Irradiation with CK-driven IIR significantly increased the invasion potential of U87 cells in a matrigel-based assay. In contrast to CIR, IIR was associated with increased levels of TGF-B at four days (Real time PCR), β1-integrin at 4-5 days (real-time PCR and western blot) and no elevation in phosphorylated AKT at days 4 and 5 (western blot). Our data suggests that glioma cell invasion as well as elevations of TGF-B and β1-integrin are associated with IIR and not CIR. |
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Authors:
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Alessandra Canazza; Chiara Calatozzolo; Luisa Fumagalli; Achille Bergantin; Francesco Ghielmetti; Laura Fariselli; Danilo Croci; Andrea Salmaggi; Emilio Ciusani |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-01 |
Journal Detail:
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Title: Cancer biology & therapy Volume: 12 ISSN: 1555-8576 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-7-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137842 Medline TA: Cancer Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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