| Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney disease. | |
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MedLine Citation:
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PMID: 12564723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polycystic kidney disease (PKD) in Persian cats has been increasingly reported and compared to human autosomal dominant polycystic kidney disease (ADPKD) in the last decade. In cats, however, few studies have dealt with the occurrence and hormonal determinants of hypertension, one of the most common extrarenal manifestations of ADPKD in humans. The purpose of this study was to compare Persian cats >4 years old with PKD to unaffected control cats with regard to blood pressure (BP), plasma renin activity (PRA), serum aldosterone concentration, plasma atrial natriuretic peptide (ANP) concentration, and aldosterone-to-renin ratio (ARR). Three gender- and age-matched groups were studied, each consisting of 7 cats: (1) a control group without cysts, (2) a group with mild PKD, and (3) a group with severe PKD (multiple cysts and renal enlargement). Mild renal insufficiency was found in only 1 of 14 cats with PKD. Cats with PKD had a higher mean arterial pressure (P = .04) and more often had a high ARR (P = .047) than did control cats. Tendencies toward higher diastolic and systolic arterial pressures (DAPs and SAPs, respectively) and lower PRAs were observed in cats with PKD compared to controls (.05 < P < or = .1). No significant differences were found between the groups in serum aldosterone and plasma ANP concentrations. None of the cats had echocardiographic evidence of cardiac hypertrophy. In conclusion, cats with PKD had a minor increase in mean arterial pressure compared to control cats, and half of the cats had a high ARR. |
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Authors:
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Karen M Pedersen; Henrik D Pedersen; Jens Häggström; Jørgen Koch; Annette K Ersbøll |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 17 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-02-04 Completed Date: 2003-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
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Department of Clinical Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. kap@kvl.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Aldosterone / blood* Animals Blood Pressure* Cat Diseases / blood*, physiopathology* Cats Female Kidney Failure / physiopathology, veterinary Male Polycystic Kidney Diseases / blood, physiopathology*, veterinary* Renin / blood* |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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