Document Detail


Increased maternal plasma levels of soluble vascular cell adhesion molecule-1 (VCAM-1) in pregnancy induced hypertension (PIH).
MedLine Citation:
PMID:  10860252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the reason of PIH problems may be due to the presence of increased circulating levels of cell adhesion molecules, markers of endothelial damage and leukocyte activation. The objective was to evaluate the plasma levels of soluble vascular cell adhesion molecule in maternal peripheral blood of patients with PIH (pregnancy induced hypertension) and compared to those of normal healthy women with uncomplicated pregnancy. Maternal plasma samples were prepared from peripheral venous blood collected from 10 patients with PIH and 10 matched normotensive patients with uncomplicated pregnancies. Samples were assayed for soluble VCAM-1 by specific enzyme-linked immunosorbent assay (ELISA). Women with PIH had significantly higher plasma level of soluble VCAM-1 as compared with healthy pregnant women without PIH (653.50 vs. 456.39 ng/mL, respectively, p < 0.005). Our results on the increased plasma levels of soluble VCAM-1 in patients with PIH provide evidence for endothelial activation of PIH. It suggest that increased plasma level of soluble VCAM-1 could be an early marker of the maternal syndrome of PIH.
Authors:
J Heimrath; A Krawczenko; D Duś
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ginekologia polska     Volume:  71     ISSN:  0017-0011     ISO Abbreviation:  Ginekol. Pol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374641     Medline TA:  Ginekol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Affiliation:
Department of Reproduction and Obstetrics, Medical University of Wrocław.
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MeSH Terms
Descriptor/Qualifier:
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypertension / diagnosis*
Pregnancy
Pregnancy Complications, Cardiovascular*
Vascular Cell Adhesion Molecule-1 / blood*
Chemical
Reg. No./Substance:
0/Vascular Cell Adhesion Molecule-1

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