Document Detail


Increased maternal microchimerism after open fetal surgery.
MedLine Citation:
PMID:  22992682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal-fetal cellular trafficking (MFCT) during pregnancy leads to the presence of maternal cells in the fetus and of fetal cells in the mother. Since this process may be altered in cases of pregnancy complications, we asked whether open fetal surgery leads to changes in microchimerism levels. We analyzed maternal and fetal microchimerism in fetuses who underwent open fetal surgery for repair of spina bifida and compared their levels to patients who had postnatal repair and to healthy controls. We found that maternal microchimerism levels were increased in patients who had open fetal surgery compared with controls. In contrast, patients who had fetal intervention at the time of delivery did not demonstrate increased microchimerism. These results suggest that open fetal surgery may alter trafficking. Given the importance of MFCT in maternal-fetal tolerance, we discuss potential implications for the field of preterm labor and transplantation tolerance.
Authors:
Payam Saadai; Tippi C MacKenzie
Publication Detail:
Type:  Journal Article     Date:  2012-07-01
Journal Detail:
Title:  Chimerism     Volume:  3     ISSN:  1938-1964     ISO Abbreviation:  Chimerism     Publication Date:    2012 Jul-Dec
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-06-20     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101540510     Medline TA:  Chimerism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Affiliation:
Division of Pediatric Surgery and The Fetal Treatment Center, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Chimerism*
Female
Fetoscopy*
Histocompatibility, Maternal-Fetal
Humans
Maternal-Fetal Exchange
Pregnancy
Transplantation Tolerance
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