Document Detail


Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics.
MedLine Citation:
PMID:  3688227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of olive oil administration on lymphocyte transport through mesenteric lymphatics was examined to see the possible involvement of nutritional absorption in lymphocyte traffic from the intestinal mucosa. After the olive oil administration to rats, remarkable increase in lymphocyte flux was observed within 2 h in lymph samples collected from rats with lymphatic fistula. The use of a high-speed microscopic video system made it possible to analyze accurately the lymphocyte transport in rapid movement that could not be detected by any of the ordinary video systems. The direct observation of mesenteric collecting lymphatics by this system showed an increment of lymphocyte transport from the intestinal mucosa by lipid absorption in 2 h. The contraction frequency of intestinal collecting lymphatics was also enhanced by olive oil administration. The densitometric analysis on video image was applied to estimate the extent of lipid absorption. The combination of a high-speed video system and the densitometric analysis revealed that the increase in lymphocyte flux occurred before lipid absorption reached its maximum and also demonstrated that the lymphocyte transport returned to control levels under the maximal absorptive condition. The results suggest that the fat absorption could be an important factor influencing the lymphocyte transport in the lymphatic system of intestine.
Authors:
S Miura; E Sekizuka; H Nagata; C Oshio; H Minamitani; M Suematsu; M Suzuki; Y Hamada; K Kobayashi; H Asakura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  253     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-06     Completed Date:  1988-01-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G596-600     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Biological Transport
Dietary Fats, Unsaturated
Image Processing, Computer-Assisted
Lipid Metabolism*
Lymph / metabolism
Lymphatic System / cytology,  drug effects,  metabolism*
Lymphocytes / metabolism*
Male
Mesentery / anatomy & histology*
Plant Oils / pharmacology
Proteins / metabolism
Rats
Rats, Inbred Strains
Triglycerides / metabolism
Video Recording
Chemical
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Plant Oils; 0/Proteins; 0/Triglycerides; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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