| Increased lymphocyte sister chromatid exchange frequency in workers with exposure to low level of ethylene dichloride. | |
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MedLine Citation:
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PMID: 11027964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genotoxicity of low-level exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) in humans is not clear. We used lymphocyte sister chromatid exchange (SCE) frequency as a parameter to investigate the genotoxicity of low level EDC and VCM in VCM-manufacturing workers. The SCE frequency was determined for 51 male workers with exposure to VCM and/or EDC and for 20 male workers devoid of such exposure. Epidemiological data were obtained by questionnaire, and included history of smoking, drinking, and any medication taken, as well as a detailed occupational history. Personal- and area-sampling and analysis were conducted in order to calculate the time-weighted average (TWA) contaminant-exposure level corresponding to different job categories. Moderate EDC exposure around 1 ppm corresponded to a significantly greater SCE frequency than was the case for the low EDC exposure group (p<0.01). However, VCM exposure of similar level was not associated with increased SCE. We conclude that EDC may cause genotoxicity at a relatively low level of exposure. |
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Authors:
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T J Cheng; P Y Chou; M L Huang; C L Du; R H Wong; P C Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 470 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-27 Completed Date: 2000-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Affiliation:
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Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan. tcheng@ha.mc.ntu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ethylene Dichlorides / toxicity* Humans Lymphocytes / drug effects*, ultrastructure Male Middle Aged Mutagens / toxicity* Occupational Exposure* Sister Chromatid Exchange* |
| Chemical | |
Reg. No./Substance:
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0/Ethylene Dichlorides; 0/Mutagens; 107-06-2/ethylene dichloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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