Document Detail


Increased lymphocyte micronucleus frequency in early pregnancy is associated prospectively with pre-eclampsia and/or intrauterine growth restriction.
MedLine Citation:
PMID:  20581221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genome stability is essential for normal foetal growth and development. To date, genome stability in human lymphocytes has not been studied in relation to late pregnancy diseases, such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR), which can be life-threatening to mother and baby and together affect >10% of pregnancies. We performed a prospective cohort study investigating the association of maternal chromosomal damage in mid-pregnancy (20 weeks gestation) with pregnancy outcomes. Chromosome damage was measured using the cytokinesis-block micronucleus cytome (CBMNcyt) assay in peripheral blood lymphocytes. The odds ratio for PE and/or IUGR in a mixed cohort of low- and high-risk pregnancies (N = 136) and a cohort of only high-risk pregnancies (N = 91) was 15.97 (P = 0.001) and 17.85 (P = 0.007), respectively, if the frequency of lymphocytes with micronuclei (MN) at 20 weeks gestation was greater than the mean + 2 SDs of the cohort. These results suggest that the presence of lymphocyte MN is significantly increased in women who develop PE and/or IUGR before the clinical signs or symptoms appear relative to women with normal pregnancy outcomes. The CBMNcyt assay may provide a new approach for the early detection of women at risk of developing these late pregnancy diseases and for biomonitoring the efficacy of interventions to reduce DNA damage, which may in turn ameliorate pregnancy outcome.
Authors:
D L F Furness; G A Dekker; W M Hague; T Y Khong; M F Fenech
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-25
Journal Detail:
Title:  Mutagenesis     Volume:  25     ISSN:  1464-3804     ISO Abbreviation:  Mutagenesis     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-12-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  489-98     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Robinson Institute, Research Centre for Reproductive Health, The Medical School, Frome Road, University of Adelaide, Adelaide, South Australia, 5005, Australia. denise.furness@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / pathology
Biological Markers / metabolism
Body Mass Index
Cohort Studies
Cytokinesis
DNA Damage
Female
Fetal Growth Retardation / pathology*
Humans
Lymphocytes / metabolism,  pathology*
Micronuclei, Chromosome-Defective*
Odds Ratio
Pre-Eclampsia / pathology*
Pregnancy
Pregnancy Outcome
Prospective Studies
Risk Factors
Smoking / adverse effects
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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