| Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia. | |
| | |
MedLine Citation:
|
PMID: 21436352 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Neutrophil activation state and its relationship with an inflammatory environment in community-acquired pneumonia (CAP) remain insufficiently elucidated. We aimed to evaluate the neutrophil apoptosis and cytokine pattern in CAP patients after 72 hours of treatment, and their impact on infection resolution. Apoptosis of blood and bronchoalveolar lavage (BAL) neutrophils was measured in nonresponding CAP (NCAP), in responding CAP (blood only) and in patients without infection (control). Pro-inflammatory (IL-6, IL-8) and anti-inflammatory (IL-10) cytokines were measured. Main outcomes were clinical stability and days of hospitalization. Basal neutrophil apoptosis was higher in BAL and blood of NCAP whereas spontaneous apoptosis (after 24 h culture) was lower. Cytokines in NCAP were higher than in responding CAP and control: IL-6 was increased in BAL and blood, IL-8 in BAL and IL-10 in blood. An increased basal apoptosis (≥20%) in BAL of NCAP was associated with lower systemic IL-10 (p<0.01), earlier clinical stability (p=0.05) and shorter hospital stay (p=0.02). A significant correlation was found for systemic IL-6 and IL-10 with days to reach stability and length of stay. After 72 hours of treatment, an increased basal alveolar neutrophil apoptosis might contribute to downregulate inflammation and to faster clinical stability. |
| | |
Authors:
|
I Moret; M J Lorenzo; B Sarria; E Cases; E Morcillo; M Perpiñá; J M Molina; R Menéndez |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
|
Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
School of Medicine, University of Valencia Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Short term safety of thoracoscopic talc pleurodesis for recurrent primary spontaneous pneumothorax.
Next Document: Pseudomonas aeruginosa induces VEGF synthesis in airway epithelium in vitro and in vivo.