| Increased luminal mucin does not disturb glucose or ovalbumin absorption in rats fed insoluble dietary fiber. | |
| | |
MedLine Citation:
|
PMID: 16988114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We tested whether increased mucin secretion due to ingestion of insoluble dietary fiber (IDF) affects small intestinal nutrient absorption in rats. Polystyrene foam (PSF) with a true expansion ratio of 54.9 was used as a model for IDF with high bulk-forming properties. In Expt. 1, rats were fed a control diet or diet containing 50 g PSF/kg for 1, 3, 5, or 7 d. Small intestinal mucin fractions were isolated, and O-linked oligosaccharide chains were measured. The luminal mucin content reached a maximum within 5 d after PSF ingestion. In Expt. 2, rats were fed a control diet or diet containing 50 g PSF/kg for 7 d, and then all rats were switched to the control diet for 1, 3, or 5 d. The increased capacity for luminal mucin secretion disappeared within 5 d after ceasing PSF ingestion. In Expt. 3, rats were fed a control diet or diet containing 70 g PSF/kg for 7 d. Glucose (1g/kg) was administered orally after 12 h of food deprivation. The blood glucose concentrations did not differ between the groups. In Expt. 4, rats were fed a control diet or diet containing 90 g PSF/kg for 14 d. At d 7, portal cannulae were installed. A mixed solution of glucose (1g/kg) and ovalbumin (OVA, 250 mg/kg) was orally administered after 12 h of food deprivation, and responses of portal glucose and OVA concentrations were monitored for 120 min. Although luminal mucin contents were almost doubled in the 9% PSF group compared with the control group, neither portal glucose nor OVA concentration differed at any time point. The results suggest that the short-term ingestion of IDF significantly increases the luminal mucin content, but that this does not disturb nutrient absorption. |
| | |
Authors:
|
Tatsuya Morita; Hiroki Tanabe; Hiroyuki Ito; Shunsuke Yuto; Takeshi Matsubara; Tsukasa Matsuda; Kimio Sugiyama; Shuhachi Kiriyama |
Related Documents
:
|
8737834 - Effects of feed antibiotic avoparcine on organ morphology in broiler chickens. 16512934 - High-viscosity carboxymethylcellulose reduces carbachol-stimulated intestinal chloride ... 6358444 - Lectins and the intestine. 10807894 - Absorption of calcium and magnesium in patients with intestinal resections treated with... 17643264 - Chronic consumption of a low-fat diet leads to increased hypothalamic agouti-related pr... 2029014 - Effects of acetylsalicylic acid on renal function in patients with chronic heart failure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of nutrition Volume: 136 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-21 Completed Date: 2006-10-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 2486-91 Citation Subset: IM |
Affiliation:
|
Faculty of Nutritional Sciences, University of Shizuoka, Yada 52-1, Shizuoka 422-8526, Japan. actmori@agr.shizuoka.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbohydrate Conformation Dietary Fiber / administration & dosage* Electrophoresis, Polyacrylamide Gel Food Deprivation Glucose / administration & dosage, pharmacokinetics* Glucose Tolerance Test Intestinal Absorption / physiology* Intestine, Small / metabolism Male Mucins / analysis, chemistry, secretion* Oligosaccharides / analysis, chemistry Ovalbumin / administration & dosage, pharmacokinetics* Polystyrenes Rats Rats, Sprague-Dawley Rats, Wistar Solubility |
| Chemical | |
Reg. No./Substance:
|
0/Mucins; 0/Oligosaccharides; 0/Polystyrenes; 50-99-7/Glucose; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for...
Next Document: A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipop...